Elon Musk spent over $250 million to help elect TrumpSilo Pharma CEO Eric Weisblum buys $4,625 in company stock

A wild first season of the expanded Big 12 is down to what should be a chaotic final weekend. Through all the upsets, unexpected rises and falls, there are nine teams still in the mix to play in the conference championship game. No. 14 Arizona State and No. 17 Iowa State have the best odds, yet a multitude of scenarios could play out — 256 to be exact. There's even the possibility of an eight-team tie. It may take a mathematician to figure out which teams are in the Dec. 7 game in Arlington, Texas — even for the ones who win. Travis Hunter, Colorado. The Buffaloes' two-way star has excelled on both sides of the field, making him one of the favorites to win the Heisman Trophy. Cam Skattebo, Arizona State. The senior running back can do a little of everything, but excels at punishing would-be tacklers. He's one of the nation's leaders in yards after contact and the focal point of the Sun Devils' offense. Shadeur Sanders, Colorado. If it weren't for Hunter, Sanders might be the Heisman favorite. The son of coach Deion Sanders, Shedeur is fifth nationally with 3,488 yards passing and has been a big part of the Buffaloes' turnaround. DJ Giddens, Kansas State. The Wildcats' running back is one of the nation's most versatile players. He is ninth nationally with 1,271 rushing yards and has added 21 receptions for 258 yards. Tetairoa McMillan, Arizona. The Wildcats have struggled this season, but McMillan has not. He is third nationally with 1,251 receiving yards with seven touchdowns on 78 catches. Jacob Rodriguez, Texas Tech. The Red Raiders' junior linebacker leads the Big 12 with 68 tackles, averaging 10.2 per game. He also has four sacks. Brendan Mott, Kansas State. He's a menace to opposing quarterbacks, leading the Big 12 with 8 1/2 sacks. The Big 12 has nine teams already bowl eligible and two more a win away. The winner of the Big 12 championship game will be in the mix for a College Football Playoff spot. Arizona State, Iowa State, No. 19 BYU, Colorado, Kansas State, Baylor, TCU, Texas Tech and West Virginia have already clinched bowl berths. Kansas and Cincinnati can get into the postseason with wins this weekend. Gus Malzahn, UCF. Despite successes in recruiting, the Knights are 10-14 in two seasons since moving to the Big 12. Maybe not enough to get shown the door this year, but another mediocre season could lead UCF to make a change. Kyle Whittingham, Utah. Whittingham was one of the Pac-12's best coaches, leading the Utes to consecutive conference titles. Utah was expected to contend for the Big 12 title its first year in the league, but enters the final weekend 1-7 in conference play, which could push Whittingham toward retirement since it's doubtful he'd be fired. Neal Brown, West Virginia. The Mountaineers' coach was in a precarious spot at the end of last season and West Virginia hasn't lived up to expectations this season. The Mountaineers are eligible to go to a bowl game for the second straight season, but Brown could be on the hot seat even after signing a contract extension before the season. Josiah Trotter, West Virginia. The redshirt freshman is the latest Trotter to have success at the linebacker position, following the footsteps of his father, former Philadelphia Eagles player Jeremiah Trotter, and brother Jeremiah Trotter Jr., a current Eagles linebacker. Sam Leavitt, Arizona State. The Michigan State transfer has been just what the Sun Devils' needed: an agile quarterback who extends plays with his legs and rarely makes bad decisions. Bryson Washington, Baylor. The Bears' running back has rushed for 812 yards — 196 against TCU — and 10 TDs. TCU has the Big 12's highest rated 2025 recruiting class with six four-star players among 26 commitments, according to the 247 Sports composite. Receiver Terry Shelton of Carrollton, Texas, is the highest-rated recruit at 71st nationally. Baylor is next with five five-star players among its 20 commitments, including running back Michael Turner, rated 13th at his position out of North Richland Hills, Texas. Texas Tech is ranked seventh in the Big 12, but has four four-star recruits. Get local news delivered to your inbox!

Gus Malzahn is leaving his post as UCF's head coach to reunite with Florida State coach Mike Norvell as the Seminoles' offensive coordinator, ESPN reported on Saturday. Norvell, who served as a graduate assistant under Malzahn at Tulsa in 2007-08, relinquished his role as FSU's primary playcaller amid a staff shakeup this season.WASHINGTON (AP) — President-elect Donald Trump 's team still hasn't signed agreements that are required to formally begin the transition process to the White House — meaning the government can't provide security clearances and briefings to incoming administration officials and the FBI can't screen his rush of picks for the Cabinet and other key posts. Read this article for free: Already have an account? To continue reading, please subscribe: * WASHINGTON (AP) — President-elect Donald Trump 's team still hasn't signed agreements that are required to formally begin the transition process to the White House — meaning the government can't provide security clearances and briefings to incoming administration officials and the FBI can't screen his rush of picks for the Cabinet and other key posts. Read unlimited articles for free today: Already have an account? WASHINGTON (AP) — President-elect Donald Trump ‘s team still hasn’t signed agreements that are required to formally begin the transition process to the White House — meaning the government can’t provide security clearances and briefings to incoming administration officials and the FBI can’t screen his rush of picks for the Cabinet and other key posts. The importance of strenuous federal background screenings — and the fact that Trump’s team has not been subjecting the president-elect’s selections to such vetting — was evident Thursday, when former Florida Rep. Matt Gaetz withdrew as Trump’s pick for attorney general following continued scrutiny over a federal sex trafficking investigation that cast doubt on whether he could be confirmed by the Senate. The continued delay on agreeing to start the formal transition process may eventually force senators to vote on Trump’s choices without the benefit of the usual background checks. That process is designed to uncover personal problems, criminal histories and other potential red flags that would raise questions about a nominee’s suitability for key jobs. Beyond the top personnel picks that Trump already has announced, good governance activists and other experts on the transition process have warned for weeks that refusing to sign the transition documents will make it impossible for potentially hundreds of Trump national security appointees to get clearances. And that means the new administration won’t be fully prepared to govern when Trump takes power on Inauguration Day on Jan. 20, 2025. Here’s a look at where things stand and what effect the delay might have: What hasn’t the Trump team signed and why? At issue are memorandums of understanding under which the incoming administration agrees to work with the outgoing one while also submitting requests for name and background checks. The FBI then commits to flagging to the White House any adverse information uncovered during the process. Congressionally mandated ethics disclosures and donor contribution limits are required as part of the agreements needed to begin the transition process. A reluctance to comply with those has been a factor in the Trump team’s hesitance to sign them, according to a person familiar with the process who spoke on condition of anonymity to discuss internal discussions. Is it too late? No. There’s still time for the agreements to be signed. A Justice Department spokesperson said discussions were ongoing with the Trump transition team, which did not respond to a request for comment on Thursday. But transition spokesman Brian Hughes said earlier this month that the team’s “lawyers continue to constructively engage with” lawyers and officials from President Joe Biden ‘s outgoing administration and promised updates “once a decision is made.” In the meantime, Trump’s team has relied on internal campaign aides, allied groups and outside law firms to support its personnel effort. Trump for years has regarded FBI leadership with suspicion — in part because of the Russian election interference investigation that shadowed his first term, and more recently because of FBI investigations into his hoarding of classified documents and his efforts to undo the results of the 2020 election that led to his indictment last year. What effect is this having? During a normal transition period, the new administration uses the time before taking office to begin working to fill 4,000 government positions with political appointees, or people who are specifically tapped for their jobs by Trump’s team. That includes everyone from the secretary of state and other heads of Cabinet departments to those selected to serve part-time on boards and commissions. Around 1,200 of those presidential appointments require Senate confirmation — which should be easier with the Senate shifting to Republican control in January. Trump has moved at record-setting speed to announce his key picks, and Senate GOP leaders say they plan to launch confirmation hearings as soon as the new Congress convenes on Jan. 3 — potentially allowing them to begin voting on nominees as soon as Inauguration Day. But lawmakers also are complaining about what they see as insufficient screening of the picks they’re being asked to consider. Some Senate Republicans have expressed concern about alleged wrongdoing by some Trump selections and two Democratic House members — Don Beyer of Virginia and Ted Lieu of California — introduced a proposal seeking to codify the FBI’s role in the background check process for political appointees of the president. And, while Gaetz is no longer an issue, he’s not the only Trump pick with an eyebrow-raising background. The president-elect’s nominee to be defense secretary, former Fox News personality Pete Hegseth, was accused of sexual assault in 2017 after a speaking appearance at a Republican women’s event in Monterey, California, but was not charged after a police investigation. A police report released Thursday contains graphic details of the sexual assault allegations. The selection of former Democratic Rep. Tulsi Gabbard for director of national intelligence has alarmed some U.S. intelligence analysts. They point to her past criticism of Ukraine, comments supportive of Russia and meetings with Syrian President Bashar Assad, a close ally of Russia and Iran. What effect will this have? Incoming members of Trump’s administration aren’t getting briefings and other information from their outgoing Biden administration counterparts that can help them better prepare for their new jobs. And Trump appointees with positions involving a security clearance won’t be able to begin work without a required background check. Once the president-elect takes office, however, he could simply order that officials be given a security clearance, as he was reported to have done for son-in-law Jared Kushner during his first term. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. Whether the delay thus far will have any longer-term effects is impossible to yet know. The delayed process may not matter much given that Trump has already served as president and has a much better understanding of how to run an administration than he did in 2016, when he won his first term. But there is precedent for problems. The 9/11 Commission suggested that the disputed election of 2000 — which delayed the start of the transition between outgoing President Bill Clinton and incoming President George W. Bush until December — raised questions about national security gaps from one administration to the other that may have contributed to the U.S. being underprepared for the Sept. 11 attacks the following year. The “36-day delay cut in half the normal transition period,” which constituted a “loss of time that hampered the new administration in identifying, recruiting, clearing and obtaining Senate confirmation of key appointees” the commission’s report stated in 2004. ___ Advertisement Advertisement

Facing SC State, Georgia aims for best start in nearly a century

The AP Top 25 men’s college basketball poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . EASTON, Pa. (AP) — Nehemiah Benson’s 28 points helped Binghamton defeat LIU 75-70 in overtime on Saturday. Benson had seven rebounds for the Bearcats (3-6). Tymu Chenery shot 7 for 12, including 3 for 5 from beyond the arc to add 18 points. Wes Peterson had 10 points and shot 3 of 4 from the field and 4 for 6 from the line. Gavin Walsh’s layup with 2 seconds remaining in regulation tied it for Binghamton. Jamal Fuller led the way for the Sharks (3-6) with 27 points and 10 rebounds. Terell Strickland added 17 points and eight assists for LIU. Malachi Davis also had 12 points. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Thomas scores 19, Rhode Island beats Providence 69-63

Syrian army announces temporary withdrawal from Aleppo after rebel assault(Reuters) -Constellation Energy is asking U.S. regulators to make new rules for connecting customers directly to power plants, saying insufficient guidance has let electric utilities unfairly thwart attempts to site, or co-locate, data centers at its nuclear facilities. In a complaint filed against grid operator PJM Interconnection with the Federal Energy Regulatory Commission on Friday, Constellation asked for a fast-tracked review to set rules that would govern connecting fully isolated co-located customers. Constellation, the largest operator of U.S. nuclear power plants, said that some of its own projects to develop data centers at power plant sites are being stymied by the lack of clarity. Its Limerick site in Pennsylvania is being threatened by the lack of rules governing co-location by PJM, the largest U.S. grid operator that oversees supply in a 13-state region, it added. Co-location allows energy-intensive customers like data centers to quickly access large amounts of electricity directly from power plants instead of waiting in lengthy lines to connect to the broader grid. The arrangements have promised to expedite Big Tech’s generative artificial intelligence expansion and have propelled company shares of Constellation this year on the prospect of signing multiple co-located power deals. Co-location has also drawn recent criticism from utilities and regulators, which have warned that the deals create power reliability risks by diverting electricity from the grid and threaten to raise power bills. FERC earlier this month rejected an agreement to increase the power capacity of an Amazon data center connected directly to Talen Energy’s Susquehanna nuclear power plant in Pennsylvania, citing risks to grid reliability and a rise in costs for consumers. Constellation backed Talen in that regulatory battle brought by utilities Exelon and American Electric Power. “Utilities have taken the law into their own hands and are unilaterally blocking co-location projects unless the future data center customers accede to utility demands,” Constellation said in its complaint. Those demands include requiring the projects take certain transmission and distribution services from the utility or its affiliates, Constellation said. It said Exelon refused to complete interconnection work at the LaSalle nuclear plant in Illinois for a new co-located data center. Constellation said the refusal could cost it $15 million to $19 million. Blocking or delaying data center power supply could set back the U.S. technology industry in the global race to dominate AI and threaten national security, Constellation argued. Exelon told Reuters on Tuesday that it would participate in the FERC proceeding and advocate for policies that were fair, support reliability and affordable power prices. “Exelon fully supports efforts to foster innovation and enhance national security, and supports customers’ rights to co-locate with generators safely, reliably, and in compliance with established rates,” Exelon said in an email. PJM and Constellation did not immediately respond to requests for comment. (Reporting by Laila Kearney in New York and Sourasis Bose in Bengaluru; Editing by Sriraj Kalluvila and Marguerita Choy) Disclaimer: This report is auto generated from the Reuters news service. ThePrint holds no responsibilty for its content. var ytflag = 0;var myListener = function() {document.removeEventListener('mousemove', myListener, false);lazyloadmyframes();};document.addEventListener('mousemove', myListener, false);window.addEventListener('scroll', function() {if (ytflag == 0) {lazyloadmyframes();ytflag = 1;}});function lazyloadmyframes() {var ytv = document.getElementsByClassName("klazyiframe");for (var i = 0; i < ytv.length; i++) {ytv[i].src = ytv[i].getAttribute('data-src');}} Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );Amazon Offering Kindle Unlimited For Just 99p in the UK

NEW YORK — The gunman who stalked and killed UnitedHealthcare CEO Brian Thompson fled New York City by bus, police officials told CNN on Friday. Video of the suspected shooter leaving the scene of the shooting Wednesday showed him riding a bicycle to Central Park and later taking a taxi cab to a bus depot, Chief of Detectives Joseph Kenny told CNN. Here's the latest: Police believe gunman who killed UnitedHealthcare CEO has left New York City The gunman who killed the CEO of the largest U.S. health insurer may have fled the city on a bus, New York City police officials told CNN on Friday. Video of the suspected shooter leaving the scene of the shooting Wednesday showed him riding a bicycle to Central Park and later taking a taxi cab to a bus depot, Chief of Detectives Joseph Kenny told CNN. “We have reason to believe that the person in question has left New York City,” Commissioner Jessica Tisch said. Gunman’s steps after killing UnitedHealthcare’s CEO give police new clues The gunman who killed the CEO of the largest U.S. health insurer made sure to wear a mask during the shooting yet left a trail of evidence in view of the nation’s biggest city and its network of security cameras that have aided authorities piecing together his movements and his identity. A law enforcement official said Friday that new surveillance footage shows the suspect riding the subway and visiting establishments in Manhattan and provided more clues about his actions in the days before he ambushed UnitedHealthcare CEO Brian Thompson . The gunman’s whereabouts and identity remain unknown Friday, as did the reason for Wednesday’s killing. New York City police say evidence firmly points to it being a targeted attack . ▶ Read more about the search for the gunman For many companies, investor meetings are seen as a risk In many companies, investor meetings like the one UnitedHealthcare CEO Brian Thompson was walking to when he was fatally shot are viewed as very risky because details on the location and who will be speaking are highly publicized. “It gives people an opportunity to arrive well in advance and take a look at the room, take a look at how people would probably come and go out of a location,” said Dave Komendat, president of DSKomendat Risk Management Services, which is based in the greater Seattle area. Some firms respond by beefing up security. For example, tech companies routinely require everyone attending a major event, such as Apple’s annual unveiling of the next iPhone or a shareholder meeting, to go through airport-style security checkpoints before entering. Others forgo in-person meetings with shareholders. ▶ Read more about how companies protect their leaders Police have obtained other surveillance images of the person wanted for questioning Those images include New York’s subway system, a law enforcement official said. In establishments where the person was captured on camera, he always appeared to pay with cash, the official said. The official wasn’t authorized to discuss details of the ongoing investigation and spoke to The Associated Press on condition of anonymity. — Mike Balsamo Another health insurer taking precautions after the shooting Medica, a Minnesota-based nonprofit health care firm that serves 1.5 million customers in 12 states, said it’s temporarily closing all six locations. The firm has offices in Minnesota, Wisconsin, Nebraska and North Dakota, and employs about 3,000 people. Employees will work from home, Medica spokesman Greg Bury said in an email Friday. “The safety of Medica employees is our top priority and we have increased security both for all of our employees,” a statement from Medica said. “Although we have received no specific threats related to our campuses, our office buildings will be temporarily closed out of an abundance of caution.” Bury also said biographical information on the company’s executives was taken down from its website as a precaution. Government health insurance provider Centene Corp. says its Investor Day will now be virtual The insurer cited the fatal shooting of UnitedHealthcare CEO Brian Thompson in its announcement about the Dec. 12 event. “All of us at Centene are deeply saddened by Brian Thompson’s death and want to express our support for all of those affected. Health insurance is a big industry and a small community; many members of the CenTeam crossed paths with Brian during their careers,” Centene CEO Sarah M. London said in a news release. “He was a person with a deep sense of empathy and clear passion for improving access to care. Our hearts are with his family and his colleagues during this difficult time.” Centene Corp. has grown in recent years to become the largest insurer in Medicaid, the state- and federally funded program that covers care for people with low incomes. Insurers manage Medicaid coverage for states, and Centene has more than 13 million people enrolled in that coverage. UnitedHealth Group says it’s focused on supporting Brian Thompson’s family The insurance company also said it’s focused on ensuring the safety of employees and assisting investigators. “While our hearts are broken, we have been touched by the huge outpouring of kindness and support in the hours since this horrific crime took place,” the company said. NY Mayor Eric Adams provided no new information on investigation’s progress during interviews But he said Friday that he’s confident police will arrest the shooter. “We are on the right road to apprehend him and bring him to justice,” Adams said on TV station WPIX. Hours after the shooting, UnitedHealthcare removed photographs of its executives from its website Later, it removed their names and biographies entirely. Investigators believe the suspect may have traveled to NY last month on a bus that originated in Atlanta Police and federal agents have been collecting information from Greyhound in an attempt to identify the suspect and are working to determine whether he purchased the ticket to New York in late November, a law enforcement official said. Investigators were also trying to obtain additional information from a cellphone recovered from a pedestrian plaza through which the shooter fled. Killing of UnitedHealthcare CEO spotlights complex challenge companies face in protecting top brass The fatal shooting of Brian Thompson while walking alone on a New York City sidewalk has put a spotlight on the widely varied approaches companies take to protect their leaders against threats. Experts say today’s political, economic and technological climate is only going to make the job of evaluating threats against executives and taking action to protect them even more difficult, experts say. Some organizations have a protective intelligence group that uses digital tools such as machine learning or artificial intelligence to comb through online comments to detect threats not only on social media platforms such as X but also on the dark web, says Komendat. They look for what’s being said about the company, its employees and its leadership to uncover risks. ▶ Read more about the steps companies take to protect their leadership Police test DNA and fingerprints on discarded bottle as they hunt for UnitedHealthcare CEO’s killer Police said Thursday they found a water bottle and protein bar wrapper from a trash can near the scene of the ambush and think the suspect bought them from a Starbucks minutes before the shooting. The items were being tested by the city’s medical examiner.

Costco Wholesale Co. (NASDAQ:COST) Receives Average Recommendation of “Moderate Buy” from AnalystsLucknow: An extraordinary blend of technology and creativity was showcased in the 2nd edition of the International Digital Exhibition which opened at Kala Strot on Saturday. Open from 2pm-8pm till Dec 10, this Indo-French Cultural Exchange event organised by Alliance Francaise Lucknow (AFL) offers an experience that combines artistic brilliance with digital innovation. Visitors are welcomed into this immersive world by scanning a QR code at the entrance, which links them to apps like Maison Tangible and Starry Vault. Each of the 15 featured paintings transforms into an animated spectacle when scanned, complete with captivating music. Themes range from serene forests to vibrant fun fairs, eerie catacombs, and lush tropical gardens. The exhibition has been divided into three sections – Looki Look Activity, the La Selection Virtual Reality and the Francophonie. VR section immerses the audience in Manet's A Bar at the Folies Bergere, the historical grandeur of Notre-Dame de Paris, and the timeless allure of Our Lady. "Art transcends boundaries, and this exhibition showcases the perfect blend of French innovation and Indian diversity," said president of AFL Nishi Pandey. Dean and principal of College of Architecture, AKTU, Vandana Sehgal said, "It animates art to another level. It is culturally sound, involving two countries in a beautiful project." Stay updated with the latest news on Times of India . Don't miss daily games like Crossword , Sudoku , and Mini Crossword .By Michelle Marchante, Miami Herald (TNS) MIAMI — As her students finished their online exam, Arlet Lara got up to make a cafe con leche . Her 16-year-old son found her on the kitchen floor. First, he called Dad in a panic. Then 911. “I had a stroke and my life made a 180-degree turn,” Lara told the Miami Herald, recalling the medical scare she experienced in May 2020 in the early months of the COVID pandemic. “The stroke affected my left side of the body,” the North Miami woman and former high school math teacher said. Lara, an avid runner and gym goer, couldn’t even walk. “It was hard,” the 50-year-old mom said. After years of rehabilitation therapy and a foot surgery, Lara can walk again. But she still struggles with moving. This summer, she became the first patient in South Florida to get an implant of a new and only FDA-approved nerve stimulation device designed to help ischemic stroke survivors regain movement in their arms and hands. This first procedure was at Jackson Memorial Hospital in Miami. Lara’s rehab was at at the Christine E. Lynn Rehabilitation Center for The Miami Project to Cure Paralysis, part of a partnership between Jackson Health System and UHealth. Every year, thousands in the United States have a stroke , with one occurring every 40 seconds, according to the U.S. Centers for Disease Control and Prevention. The majority of strokes are ischemic, often caused by blood clots that obstruct blood flow to the brain. For survivors, most of whom are left with some level of disability, the Vivistim Paired VNS System, the device implanted in Lara’s chest, could be a game changer in recovery, said Dr. Robert Starke, a UHealth neurosurgeon and interventional neuroradiologist. He also serves as co-director of endovascular neurosurgery at Jackson Memorial Hospital, part of Miami-Dade’s public hospital system. Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, right, runs into her rehabilitation neurology physician Dr. Gemayaret Alvarez, before her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant designed to help stroke survivors regain function in their arms, goes through exercises while her therapist activates the device during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The activation works as positive reinforcement to her muscles when she completes the exercise correctly. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, does an exercise while Neil Batungbakal, rehabilitation therapist, activates the implant with the black trigger during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. The activation works as positive reinforcement to her muscles when she completes the exercise correctly. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA- approved nerve stimulation implant, does an exercise while Neil Batungbakal, rehabilitation therapist, activates the implant with the black trigger during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, right, runs into her rehabilitation neurology physician Dr. Gemayaret Alvarez, before her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. (Alie Skowronski/Miami Herald/TNS) The Vivistim Paired VNS System is a small pacemaker-like device implanted in the upper chest and neck area. Patients can go home the same day. The U.S. Food and Drug Administration approved the stroke rehabilitation system in 2021 to be used alongside post-ischemic stroke rehabilitation therapy to treat moderate to severe mobility issues in hands and arms. Lara’s occupational therapist can activate the device during rehabilitation sessions to electrically stimulate the vagus nerve, which runs from the brain down to the abdomen and regulates various parts of the body’s nervous system. The electrical stimulation rewires the brain to improve a stroke survivor’s ability to move their arms and hands. Lara also has a magnet she can use to activate the device when she wants to practice at home. Her therapy consists of repetitive tasks, including coloring, pinching cubes and grabbing and releasing cylindrical shapes. After several weeks of rehabilitation therapy with the device, Lara has seen improvement. “Little by little, I’m noticing that my hand is getting stronger. I am already able to brush my teeth with the left hand,” she told the Miami Herald in September. Since then, Lara has finished the initial six-week Vivitism therapy program, and is continuing to use the device in her rehabilitation therapy. She continues to improve and can now eat better with her left hand and can brush her hair with less difficulty, according to her occupational therapist, Neil Batungbakal. Lara learned about the device through an online group for stroke survivors and contacted the company to inquire. She then connected them with her Jackson medical team. Now a year later, the device is available to Jackson patients. So far, four patients have received the implant at Jackson. Related Articles Starke sees the device as an opportunity to help bring survivors one step closer to regaining full mobility. Strokes are a leading cause of disability worldwide. While most stroke survivors can usually recover some function through treatment and rehabilitation, they tend to hit a “major plateau” after the first six months of recovery, he said. Vivistim, when paired with rehabilitation therapy, could change that. Jackson Health said results of a clinical trial published in the peer-reviewed medical journal The Lancet in 2021 showed that the device, “when paired with high-repetition, task-specific occupational or physical therapy, helps generate two to three times more hand and arm function for stroke survivors than rehabilitation therapy alone.” The device has even shown to benefit patients 20 years from their original stroke, according to Starke. “So now a lot of these patients that had strokes 10-15 years ago that thought that they would never be able to use their arm in any sort of real functional way are now able to have a real meaningful function, which is pretty tremendous,” Starke said. Vivistim’s vagus-nerve stimulation technology was developed by researchers at the University of Texas at Dallas’ Texas Biomedical Device Center and is being sold commercially by Austin-based MicroTransponder, a company started by university graduates. Similar devices are used to treat epilepsy and depression . For Lara, the device is a new tool to help her recovery journey. “Everything becomes a challenge so we are working with small things every day because I want to get back as many functions as possible,” Lara said. Patients interested in Vivistim should speak with their doctor to check their eligibility. The FDA said patients should make sure to discuss any prior medical history, including concurrent forms of brain stimulation, current diathermy treatment, previous brain surgery, depression, respiratory diseases and disorders such as asthma, and cardiac abnormalities. “Adverse events included but were not limited to dysphonia (difficulty speaking), bruising, falling, general hoarseness, general pain, hoarseness after surgery, low mood, muscle pain, fracture, headache, rash, dizziness, throat irritation, urinary tract infection and fatigue,” the FDA said. MicroTransponder says the device is “covered by Medicare, Medicaid, and private insurance with prior authorization on a case-by-case basis.” To learn more about the device, visit vivistim.com. ©2024 Miami Herald. Visit at miamiherald.com. Distributed by Tribune Content Agency, LLC.