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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
Early lead, and winning streak, slip away from Wild in loss to Ottawa
Jimmy Carter, nation’s 39th president who became influential human rights advocate, diesNone
None
Defeating cancer is an achievement, but the battle often doesn’t end with the last treatment session. For many survivors, life post-cancer presents a unique set of challenges that include physical, emotional, social, and financial domains. Fatigue, chronic pain, and hormonal imbalances are just a few of the side effects that can impact daily life. Emotionally, anxiety about recurrence and depression can take over moments of relief, while cognitive issues, often termed "chemo brain," add another layer of complexity. To start living their lives like before, they need support from their loved ones. We got in touch with Dr Swapnil Kapote, Consultant Surgical Oncologist at Jupiter Hospital, Thane, who explains the challenges cancer survivors face that may help you understand their situation better. 1. Physical Side Effects Cancer treatments, including surgery, chemotherapy, and radiation, can leave physical effects that may vary from person to person. - Fatigue: “One of the most common complaints I hear from survivors is fatigue,” says Dr Kapote. “It’s not just about feeling tired; it’s a pervasive exhaustion that can last months or even years after treatment.” He recommends a combination of gentle exercise, proper nutrition, and adequate rest to help combat this issue. - Pain: Chronic pain, often stemming from surgery, nerve damage, or radiation, can be debilitating. Dr Kapote stresses the importance of pain management programs, which may include medications, physical therapy, or alternative therapies like acupuncture. - Lymphedema: Swelling, particularly in the arms or legs, may occur following lymph node removal. “Patients should work closely with their care team to manage this condition through compression garments, exercises, or specialized therapy,” he advises. - Hormonal Changes: Treatments affecting the endocrine system can cause weight fluctuations, hot flashes, or sexual dysfunction. “These changes can impact quality of life significantly, and addressing them often requires a multidisciplinary approach,” Dr Kapote adds. - Organ Function: Heart, lung, kidney, or liver function can be affected by cancer therapies. Survivors require ongoing monitoring to identify and manage any complications early. 2. Psychological and Emotional Challenges The emotional impact of surviving cancer is profound. - Anxiety and "Scanxiety": Survivors often experience anxiety during follow-ups or scans, fearing a recurrence. “Psychological counselling and mindfulness practices can help mitigate these fears,” says Dr Kapote. - Depression: Adapting to life post-treatment can lead to depression, particularly if survivors grapple with physical changes or the emotional toll of their journey. Seeking professional mental health support is crucial. - Cognitive Issues: Many survivors report “chemo brain,” a term describing difficulties with memory, focus, and mental clarity. Dr Kapote shares cognitive rehabilitation programs as effective tools for recovery. 3. Social and Relationship Dynamics Cancer often redefines personal and professional relationships. - Survivors may feel isolated as loved ones struggle to understand their post-treatment challenges. “Open communication with family and friends is key,” says Dr Kapote. - Changes in family roles can create stress, especially for those who were primary caregivers or breadwinners. - Returning to work can be tough due to fatigue or cognitive difficulties. “Employers must provide support and accommodations to ease this transition,” he said. 4. Financial Stress Cancer’s financial toll persists long after treatment. - Ongoing medical expenses for follow-ups, medications, and side effect management can strain budgets. - Lost income during treatment exacerbates financial stress. “Survivors should explore financial assistance programs and consult with insurance advisors for support,” Dr Kapote suggests. 5. Long-Term Health Monitoring Regular follow-ups are critical to detect recurrences or secondary cancers early. - Survivors are also at increased risk for long-term health conditions like cardiovascular disease or osteoporosis due to treatment side effects. - Dr Kapote recommends creating a survivorship care plan that includes routine screenings, lifestyle changes, and access to supportive resources. 6. Adapting to a New Normal The post-treatment phase is about redefining life’s priorities and embracing new routines. - “Rehabilitation programs, counselling, and support groups can help survivors navigate this transition,” Dr Kapote explains. - Holistic practices like yoga, meditation, and mindfulness can also promote mental and physical well-being. Expert Advice for Survivors Dr Kapote encourages survivors to prioritize their health and seek support whenever needed. “Survivorship is a journey that demands patience and perseverance. Surround yourself with a strong support system, stay proactive about your health, and don’t hesitate to seek help from professionals or support groups,” he said. Get Latest News Live on Times Now along with Breaking News and Top Headlines from Health and around the world.Baker Mayfield threw for five touchdowns and the Tampa Bay Buccaneers stayed in the race atop the NFC South by pounding the visiting Carolina Panthers 48-14 on Sunday afternoon. Mike Evans and Jalen McMillan both caught two TD passes and Bucky Irving rushed for 113 yards as Tampa Bay's second victory of the month against Carolina came much easier than the road version in overtime. Mayfield completed 27 of 32 passes for 359 yards and Evans caught eight balls for 97 yards. The Buccaneers (9-7) collected 551 yards of total offense. The Panthers (4-12) have lost five of their last six despite Bryce Young throwing two touchdown passes to Adam Thielen (five catches, 110 receiving yards). Young finished 15-for-28 passing for 203 yards, but Carolina managed only 39 rushing yards as it played without injured top running back Chuba Hubbard. Both of Mayfield's TD tosses to Evans were short (2 yards, 1 yard). Mayfield's scoring throws to McMillian covered 10 and 16 yards. He also had a 5-yard throw to Payne Durham to open the second-half scoring. The Buccaneers also scored off J. J. Russell's blocked punt return during a 25-second span of the third quarter when they racked up 14 points. Chase McLaughlin kicked field goals of 23 and 34 yards for the Buccaneers, who need to finish with a better record than the Atlanta Falcons in the divisional race because the tiebreaker favors Atlanta, which plays at Washington on Sunday night. Tampa Bay hosts New Orleans next weekend, while Carolina plays at Atlanta. After scoring on its first possession, Carolina's next three series on offense resulted in a total of minus-6 yards and three punts. The Buccaneers cashed in for 17 points following those defensive stops. The Panthers perked up by going 70 yards in 21 seconds to score on Young's 40-yard pass to Theilen with 50 seconds left in the half. They got the ball back following a Tampa Bay punt, and were in position to post 10 points in the last minute of the half until Eddy Pineiro's 53-yard field goal attempt was off the mark. Carolina has surrendered more points this year than in any season in franchise history, though Tampa Bay came four points shy of matching the most points ever allowed by the Panthers in a game. --Field Level Media
Investment fund backed by Peter Hargreaves records rebound in profits
Taiwan board game invites players to imagine Chinese invasion2024’s top 10 climate disasters cost more than 200 billion dollars, charity saysNEW YORK (AP) — U.S. stocks climbed Thursday after market superstar Nvidia and another round of companies said they’re making even fatter profits than expected. The S&P 500 pulled 0.5% higher after flipping between gains and losses several times during the day. Banks, smaller companies and other areas of the stock market that tend to do best when the economy is strong helped lead the way, while bitcoin briefly broke above $99,000. Crude oil, meanwhile, continued to rise. The Dow Jones Industrial Average jumped 461 points, or 1.1%, and the Nasdaq composite edged up by less than 0.1%. Nvidia rose just 0.5% after beating analysts’ estimates for profit and revenue yet again, but it was still the strongest force pulling the S&P 500 upward. It also gave a forecast for revenue in the current quarter that topped most analysts’ expectations due to voracious demand for its chips used in artificial-intelligence technology. Its stock initially sank in afterhours trading Wednesday following the release of the results. Some investors said the market might have been looking for Nvidia’s revenue forecast to surpass expectations by even more. But its stock recovered in premarket trading Thursday, and Wedbush analyst Dan Ives said it was another “flawless” profit report provided by Nvidia and CEO Jensen Huang, whom Ives calls “the Godfather of AI.” The stock meandered through Thursday as well, dragging the S&P 500 and other indexes back and forth. How Nvidia’s stock performs has more impact than any other because it’s grown into Wall Street’s most valuable company at roughly $3.6 trillion. The frenzy around AI is sweeping up other stocks, and Snowflake jumped 32.7% after reporting stronger results for the latest quarter than analysts expected. The company, whose platform helps customers get a better view of all their silos of data and use AI, also reported stronger revenue growth than expected. BJ’S Wholesale Club rose 8.3% after likewise delivering a bigger profit than expected. That may help calm worries about how resilient U.S. shoppers can remain, given high prices across the economy and still-high interest rates. A day earlier, Target tumbled after reporting sluggish sales in the latest quarter and giving a dour forecast for the holiday shopping season. It followed Walmart , which gave a much more encouraging outlook. Nearly 90% of the stocks in the S&P 500 ended up rising Thursday, and the gains were even bigger among smaller companies. The Russell 2000 index of smaller stocks jumped a market-leading 1.7%. Google’s parent company, Alphabet, helped keep indexes in check. It fell 4.7% after U.S. regulators asked a judge to break up the tech giant by forcing it to sell its industry-leading Chrome web browser. In a 23-page document filed late Wednesday, the U.S. Department of Justice called for sweeping punishments that would include restrictions preventing Android from favoring its own search engine. Regulators stopped short of demanding Google sell Android but left the door open to it if the company’s oversight committee continues to see evidence of misconduct. All told, the S&P 500 rose 31.60 points to 5,948.71. The Dow jumped 461.88 to 43,870.35, and the Nasdaq composite added 6.28 to 18,972.42. In the crypto market, bitcoin eclipsed $99,000 for the first time before pulling back toward $98,000, according to CoinDesk. It’s more than doubled so far this year, and its climb has accelerated since Election Day. President-elect Donald Trump has pledged to make the country “the crypto capital of the planet” and create a “strategic reserve” of bitcoin. Bitcoin got a further boost after Gary Gensler, the chair of the Securities and Exchange Commission, said Thursday he would step down in January . Gensler has pushed for more protections for crypto investors. Bitcoin and related investment have a notorious history of big price swings in both directions. MicroStrategy, a company that’s been raising cash expressly to buy bitcoin, saw an early Thursday gain of 14.6% for its stock quickly disappear. It finished the day with a loss of 16.2%. In the oil market, a barrel of benchmark U.S. crude rose 2% to bring its gain for the week to 4.8%. Brent crude, the international standard, climbed 1.8%. Oil has been rising amid escalations in the Russia-Ukraine war. In stock markets abroad, shares of India’s Adani Enterprises plunged 22.6% Thursday after the U.S. charged founder Gautam Adani in a federal indictment with securities fraud and conspiracy to commit securities and wire fraud. The businessman and one of the world’s richest people is accused of concealing that his company’s huge solar energy project on the subcontinent was being facilitated by an alleged bribery scheme. Stock indexes elsewhere in Asia and Europe were mixed. In the bond market, the yield on the 10-year Treasury inched up to 4.43% from 4.41% late Wednesday following some mixed reports on the U.S. economy. One said fewer U.S. workers applied for unemployment benefits last week in the latest signal that the job market remains solid. Another report, though, said manufacturing in the mid-Atlantic region unexpectedly shrank. Sales of previously occupied homes, meanwhile, strengthened last month by more than expected. AP Business Writers Matt Ott and Yuri Kageyama contributed.CLEVELAND, Ohio – A rivalry is renewed as the Cleveland Browns host the Pittsburgh Steelers today – Thursday, Nov. 21 – at Huntington Bank Field in Cleveland, Ohio. There are multiple free viewing options for fans who live in the Cleveland and Pittsburgh markets. Nationwide, the game can be watched at no cost through a free trial with Amazon Prime. This “Thursday Night Football” primetime matchup will kick off at 8:15 p.m. Eastern. For the Cleveland (WEWS) and Pittsburgh (WTAE) markets, there is the option to watch on Fubo (free trial and $30 off your first month) and DirecTV Stream (free trial). Sling has promotional offers as well. For out of market viewing, fans who have cut the cord on cable can catch the game at no cost exclusively on Amazon Prime Video with a free trial. The Browns (2-8) once again came out on the losing end in a Bayou battle with the New Orleans Saints in their last game, while the Steelers (8-2) notched their fifth win in a row, taking down the Baltimore Ravens in a juicy matchup atop the AFC North Division. Check out a complete rundown of NFL Week 12 action , including the schedule, predictions, previews, TV information and more. BROWNS-STEELERS Matchup Preview After suffering their seventh loss in eight games , the Browns will look for solace in an otherwise tumultuous campaign as they host the rival Steelers in what is expected be a wintry mix of conditions throughout the evening. After years of earning back respect in the rivalry , the Browns are now headed in the familiar opposite direction of Pittsburgh’s winning franchise. A season of expectations has spiraled into one of misery. With Deshaun Watson suffering a season-ending Achilles injury , quarterback Jameis Winston has stepped into the starting role, tossing for 1,047 yards, seven touchdowns and three interceptions. Often criticized for his ability to give the ball away, Winston has only had one game with a pick, which was a three-giveaway day against the Chargers' top-ranked defense. Throwing for nearly 400 yards inside the dome last week, the urge to air it out might disappear with unfavorable conditions expected to wreak havoc. The matchup is leaning more to an old-fashioned ground-and-pound style. The Browns rushing attack has been nonexistent. Nick Chubb has not returned to form and Jerome Ford has been held in check all season. Ford touts 57 carries for 279 yards and one touchdown. Chubb suffered a season-ending leg injury in the matchup against the Steelers last season. Wide receiver Cedric Tillman remains a strong threat. He has notched 27 receptions for 311 yards and three touchdowns, averaging 11.5 yards per reception. The Saints loss ended a streak of three straight games with 75 or more receiving yards. Tight end David Njoku has nabbed 39 receptions for 336 yards and two touchdowns, averaging 8.6 yards per reception. Kicker Dustin Hopkins missed three kicks , which nearly looked identical to each other, all hooking to the left. The missed opportunities didn’t make a difference in New Orleans, but in these conditions, they could be the determining factor. He also opposes the best kicker in the league this season, who is coming off a single-footed masterpiece. Reigning Defensive Player of the Year Myles Garrett has put up average numbers for his talent. He has 21 solo tackles, seven sacks and two forced fumbles. In the loss against the Saints, Garrett did not record a stat for the second time this season. Cleveland’s defense was shredded by Taysom Hill last week. The jack-of-all-trades tight end was unleashed. He notched seven carries for 138 yards and three touchdowns. While that carnage occurred on the ground, Cleveland is allowing 226.5 passing yards per game. The defense, which was the best in the NFL last season , has been known to give up explosives this year. Cleveland has only forced two interceptions this season, which is tied for second-last in the league. Three-time Pro Bowl cornerback Denzel Ward pocketed one of those last week. He has 17 solo tackles and a forced fumble also to his credit this season. With playoff aspirations seemingly out of reach, Cleveland is playing for pride. Spoiling Pittsburgh’s winning streak would be the highlight of the season. The Browns have split the last eight meetings and have been victorious in their last eight home games on “Thursday Night Football.” Watch Browns vs. Steelers on Amazon Prime Video for free The Steelers continue their stretch of four consecutive AFC North games with a rivalry stranglehold against the Browns that has loosened as of late, including a 13-10 loss last November. Pittsburgh’s offense has been a breath of fresh air for fans this season. With questions about their stagnant play coming in, the unit has silenced the critics with consistency. They have managed to score points in 22 consecutive quarters, which is the longest active streak in the NFL. Pittsburgh is led by veteran quarterback Russell Wilson , who has notched 942 yards and six touchdowns with two interceptions in four games. Wilson also has a rushing touchdown to his credit. Backup quarterback Justin Fields, who began the season under center, saw some limited play last game. Fields has notched 1,106 yards, five touchdowns and one interception. Expect the versatile playmaker to be thrown in for some packages to shake things up. Wide receiver George Pickens has gobbled up 48 receptions for 728 yards and two touchdowns, averaging 15.2 yards per reception. Tight end Pat Freiermuth has also found some spots, tallying 31 receptions for 295 yards and three touchdowns. He averages 9.5 yards per reception. Running back Jaylen Warren has been progressing, earning 64 carries for 258 yards. While those numbers may not look like much, they are an improvement from his totals in the opening games of the season. Warren also has 18 receptions for 123 yards. Kicker Chris Boswell scored all of Pittsburgh’s points in the victory over the Ravens. He is firing at a 96.7% clip and has scored an NFL-best 107 points this season. Pittsburgh’s defense resembles the Chargers unit that had a field day with Winston. The Steelers own the second-best turnover differential in the NFL at Plus-11, sitting only behind the Buffalo Bills. The defense has forced 19 takeaways and have only failed to snag an interception in three outings. Punishing linebacker T.J. Watt leads the defense with 27 solo tackles, 7.5 sacks and four forced fumbles. The Watt-Garrett comparison is one of many juicy storylines to this rivalry. Located just 130 miles apart, it’s the 146th rendition of Browns vs. Steelers in conditions that scream AFC North football. Live in Cleveland or Pittsburgh? Watch Browns vs. Steelers for free on FuboTV BROWNS-STEELERS Last Game Recap The Browns kept it competitive with the Saints until a 21-point fourth quarter while the Steelers snuck past the Ravens in a classic AFC North showdown. Cleveland Browns: Lost 35-14 to the New Orleans Saints on Nov. 17. Pittsburgh Steelers: Won 18-16 against the Baltimore Ravens on Nov. 17. BROWNS-STEELERS Players to Watch Cleveland’s playmakers will have another chance to shine in a wintry mix while Pittsburgh’s stars will look to steal the show on enemy soil. Cleveland Browns: QB Jameis Winston, DE Myles Garrett, RB Nick Chubb, K Dustin Hopkins, WR Cedric Tillman Pittsburgh Steelers: QB Russell Wilson, S Minkah Fitzpatrick, WR George Pickens, K Chris Bosworth, RB Jaylen Warren BROWNS-STEELERS Injuries of Note The Browns' offensive line took another hit this week while the Steelers remain relatively healthy for the primetime showdown. Cleveland Browns: OT Jedrick Wills Jr. (knee) and TE Geoff Swaim (concussion) are both out. QB Deshaun Watson (Achilles surgery), OT Dawand Jones (lower leg), RB Nyheim Hines (knee), LB Jeremiah Owusu-Koramoah (neck), OT James Hudson III (shoulder), LS Charley Hughlett (ribs), CB Tony Brown II, DT Michael Hall Jr. (knee) and C Nick Harris are all placed on injured reserve. Pittsburgh Steelers: LB Alex Highsmith (ankle) is out. CB Cory Trice Jr. (hamstring) and CB C.J. Henderson (neck) and WR Roman Wilson (hamstring) and defensive tackle Montravious Adams (knee) have all been placed on injured reserve. Buy Browns tickets for every game this season Who is announcing Browns vs. Steelers? Al Michaels (play-by-play) and Kirk Herbstreit (analyst) will be the announcers while Kaylee Hartung reports from the sidelines. What are the latest odds for Browns vs. Steelers? Spread: CLE: (+3.5), PIT: (-3.5) Moneyline: CLE: (+160), PIT: (-192) Point total: 37 Odds from DraftKings How to Watch BROWNS-STEELERS Who: Cleveland Browns vs. Pittsburgh Steelers When: Thursday, Nov. 21, 2024 Time: 8:15 p.m. Eastern Where: Huntington Bank Field | Cleveland, Ohio Channel: WEWS (Cleveland only), WTAE (Pittsburgh only) Best Streaming Options: Fubo (free trial and $30 off your first month), DirecTV Stream (free trial), Sling (promotional offers) and Amazon Prime Video (free trial) Channel finder if you have cable You can access the channel by using the channel finders online: Verizon Fios , AT&T U-verse , Comcast Xfinity , Spectrum/Charter , Optimum/Altice , DIRECTV and Dish . About FuboTV Fubo (free trial and $30 off your first month) has three main packages: Pro costs $79.99/month; Elite is $89.99; Premier is priced at $99.99. Cancel before the free trial ends to avoid being charged. Fubo includes access to more than 185 sports, entertainment and news channels. You can record games, TV shows, movies and more. About DirecTV Stream DirecTV Stream , which also gives customers a free trial, offers four packages if you continue with the service after your trial ends: Entertainment for $69.99; Choice for $84.99; Ultimate for $109.99; and premier for $159.99. Choice offers the most channels for sports enthusiasts. About Sling Sling , which features promotional offers for new customers, has a Blue package for $20 for your first month ($40 after that) and an Orange package for the same price and deal. Get both the Blue and Orange packages for $27.50 for your first month ($55 after that). RECOMMENDED • cleveland .com Browns vs. Saints: Watch Week 11 NFL live stream for free today Nov. 17, 2024, 6:00 a.m. Steelers vs. Browns predictions and best bets: Expect the unexpected in bad weather game Nov. 21, 2024, 2:00 p.m. About Amazon Prime Video Amazon Prime Video offers a 30-day free trial. If you’re an Amazon Prime member, this video service is included at no extra cost with your membership. Joining Amazon Prime costs $14.99/month or $139 annually. The streaming service features blockbuster movies, hit shows, Amazon Originals and sports, including select NFL games for the 2024 season. For team hats, shirts and more gear: Visit Fanatics , Dick’s Sporting Goods , Lids , Champs Sports and New Era .
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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
Early lead, and winning streak, slip away from Wild in loss to Ottawa
Jimmy Carter, nation’s 39th president who became influential human rights advocate, diesNone
None
Defeating cancer is an achievement, but the battle often doesn’t end with the last treatment session. For many survivors, life post-cancer presents a unique set of challenges that include physical, emotional, social, and financial domains. Fatigue, chronic pain, and hormonal imbalances are just a few of the side effects that can impact daily life. Emotionally, anxiety about recurrence and depression can take over moments of relief, while cognitive issues, often termed "chemo brain," add another layer of complexity. To start living their lives like before, they need support from their loved ones. We got in touch with Dr Swapnil Kapote, Consultant Surgical Oncologist at Jupiter Hospital, Thane, who explains the challenges cancer survivors face that may help you understand their situation better. 1. Physical Side Effects Cancer treatments, including surgery, chemotherapy, and radiation, can leave physical effects that may vary from person to person. - Fatigue: “One of the most common complaints I hear from survivors is fatigue,” says Dr Kapote. “It’s not just about feeling tired; it’s a pervasive exhaustion that can last months or even years after treatment.” He recommends a combination of gentle exercise, proper nutrition, and adequate rest to help combat this issue. - Pain: Chronic pain, often stemming from surgery, nerve damage, or radiation, can be debilitating. Dr Kapote stresses the importance of pain management programs, which may include medications, physical therapy, or alternative therapies like acupuncture. - Lymphedema: Swelling, particularly in the arms or legs, may occur following lymph node removal. “Patients should work closely with their care team to manage this condition through compression garments, exercises, or specialized therapy,” he advises. - Hormonal Changes: Treatments affecting the endocrine system can cause weight fluctuations, hot flashes, or sexual dysfunction. “These changes can impact quality of life significantly, and addressing them often requires a multidisciplinary approach,” Dr Kapote adds. - Organ Function: Heart, lung, kidney, or liver function can be affected by cancer therapies. Survivors require ongoing monitoring to identify and manage any complications early. 2. Psychological and Emotional Challenges The emotional impact of surviving cancer is profound. - Anxiety and "Scanxiety": Survivors often experience anxiety during follow-ups or scans, fearing a recurrence. “Psychological counselling and mindfulness practices can help mitigate these fears,” says Dr Kapote. - Depression: Adapting to life post-treatment can lead to depression, particularly if survivors grapple with physical changes or the emotional toll of their journey. Seeking professional mental health support is crucial. - Cognitive Issues: Many survivors report “chemo brain,” a term describing difficulties with memory, focus, and mental clarity. Dr Kapote shares cognitive rehabilitation programs as effective tools for recovery. 3. Social and Relationship Dynamics Cancer often redefines personal and professional relationships. - Survivors may feel isolated as loved ones struggle to understand their post-treatment challenges. “Open communication with family and friends is key,” says Dr Kapote. - Changes in family roles can create stress, especially for those who were primary caregivers or breadwinners. - Returning to work can be tough due to fatigue or cognitive difficulties. “Employers must provide support and accommodations to ease this transition,” he said. 4. Financial Stress Cancer’s financial toll persists long after treatment. - Ongoing medical expenses for follow-ups, medications, and side effect management can strain budgets. - Lost income during treatment exacerbates financial stress. “Survivors should explore financial assistance programs and consult with insurance advisors for support,” Dr Kapote suggests. 5. Long-Term Health Monitoring Regular follow-ups are critical to detect recurrences or secondary cancers early. - Survivors are also at increased risk for long-term health conditions like cardiovascular disease or osteoporosis due to treatment side effects. - Dr Kapote recommends creating a survivorship care plan that includes routine screenings, lifestyle changes, and access to supportive resources. 6. Adapting to a New Normal The post-treatment phase is about redefining life’s priorities and embracing new routines. - “Rehabilitation programs, counselling, and support groups can help survivors navigate this transition,” Dr Kapote explains. - Holistic practices like yoga, meditation, and mindfulness can also promote mental and physical well-being. Expert Advice for Survivors Dr Kapote encourages survivors to prioritize their health and seek support whenever needed. “Survivorship is a journey that demands patience and perseverance. Surround yourself with a strong support system, stay proactive about your health, and don’t hesitate to seek help from professionals or support groups,” he said. Get Latest News Live on Times Now along with Breaking News and Top Headlines from Health and around the world.Baker Mayfield threw for five touchdowns and the Tampa Bay Buccaneers stayed in the race atop the NFC South by pounding the visiting Carolina Panthers 48-14 on Sunday afternoon. Mike Evans and Jalen McMillan both caught two TD passes and Bucky Irving rushed for 113 yards as Tampa Bay's second victory of the month against Carolina came much easier than the road version in overtime. Mayfield completed 27 of 32 passes for 359 yards and Evans caught eight balls for 97 yards. The Buccaneers (9-7) collected 551 yards of total offense. The Panthers (4-12) have lost five of their last six despite Bryce Young throwing two touchdown passes to Adam Thielen (five catches, 110 receiving yards). Young finished 15-for-28 passing for 203 yards, but Carolina managed only 39 rushing yards as it played without injured top running back Chuba Hubbard. Both of Mayfield's TD tosses to Evans were short (2 yards, 1 yard). Mayfield's scoring throws to McMillian covered 10 and 16 yards. He also had a 5-yard throw to Payne Durham to open the second-half scoring. The Buccaneers also scored off J. J. Russell's blocked punt return during a 25-second span of the third quarter when they racked up 14 points. Chase McLaughlin kicked field goals of 23 and 34 yards for the Buccaneers, who need to finish with a better record than the Atlanta Falcons in the divisional race because the tiebreaker favors Atlanta, which plays at Washington on Sunday night. Tampa Bay hosts New Orleans next weekend, while Carolina plays at Atlanta. After scoring on its first possession, Carolina's next three series on offense resulted in a total of minus-6 yards and three punts. The Buccaneers cashed in for 17 points following those defensive stops. The Panthers perked up by going 70 yards in 21 seconds to score on Young's 40-yard pass to Theilen with 50 seconds left in the half. They got the ball back following a Tampa Bay punt, and were in position to post 10 points in the last minute of the half until Eddy Pineiro's 53-yard field goal attempt was off the mark. Carolina has surrendered more points this year than in any season in franchise history, though Tampa Bay came four points shy of matching the most points ever allowed by the Panthers in a game. --Field Level Media
Investment fund backed by Peter Hargreaves records rebound in profits
Taiwan board game invites players to imagine Chinese invasion2024’s top 10 climate disasters cost more than 200 billion dollars, charity saysNEW YORK (AP) — U.S. stocks climbed Thursday after market superstar Nvidia and another round of companies said they’re making even fatter profits than expected. The S&P 500 pulled 0.5% higher after flipping between gains and losses several times during the day. Banks, smaller companies and other areas of the stock market that tend to do best when the economy is strong helped lead the way, while bitcoin briefly broke above $99,000. Crude oil, meanwhile, continued to rise. The Dow Jones Industrial Average jumped 461 points, or 1.1%, and the Nasdaq composite edged up by less than 0.1%. Nvidia rose just 0.5% after beating analysts’ estimates for profit and revenue yet again, but it was still the strongest force pulling the S&P 500 upward. It also gave a forecast for revenue in the current quarter that topped most analysts’ expectations due to voracious demand for its chips used in artificial-intelligence technology. Its stock initially sank in afterhours trading Wednesday following the release of the results. Some investors said the market might have been looking for Nvidia’s revenue forecast to surpass expectations by even more. But its stock recovered in premarket trading Thursday, and Wedbush analyst Dan Ives said it was another “flawless” profit report provided by Nvidia and CEO Jensen Huang, whom Ives calls “the Godfather of AI.” The stock meandered through Thursday as well, dragging the S&P 500 and other indexes back and forth. How Nvidia’s stock performs has more impact than any other because it’s grown into Wall Street’s most valuable company at roughly $3.6 trillion. The frenzy around AI is sweeping up other stocks, and Snowflake jumped 32.7% after reporting stronger results for the latest quarter than analysts expected. The company, whose platform helps customers get a better view of all their silos of data and use AI, also reported stronger revenue growth than expected. BJ’S Wholesale Club rose 8.3% after likewise delivering a bigger profit than expected. That may help calm worries about how resilient U.S. shoppers can remain, given high prices across the economy and still-high interest rates. A day earlier, Target tumbled after reporting sluggish sales in the latest quarter and giving a dour forecast for the holiday shopping season. It followed Walmart , which gave a much more encouraging outlook. Nearly 90% of the stocks in the S&P 500 ended up rising Thursday, and the gains were even bigger among smaller companies. The Russell 2000 index of smaller stocks jumped a market-leading 1.7%. Google’s parent company, Alphabet, helped keep indexes in check. It fell 4.7% after U.S. regulators asked a judge to break up the tech giant by forcing it to sell its industry-leading Chrome web browser. In a 23-page document filed late Wednesday, the U.S. Department of Justice called for sweeping punishments that would include restrictions preventing Android from favoring its own search engine. Regulators stopped short of demanding Google sell Android but left the door open to it if the company’s oversight committee continues to see evidence of misconduct. All told, the S&P 500 rose 31.60 points to 5,948.71. The Dow jumped 461.88 to 43,870.35, and the Nasdaq composite added 6.28 to 18,972.42. In the crypto market, bitcoin eclipsed $99,000 for the first time before pulling back toward $98,000, according to CoinDesk. It’s more than doubled so far this year, and its climb has accelerated since Election Day. President-elect Donald Trump has pledged to make the country “the crypto capital of the planet” and create a “strategic reserve” of bitcoin. Bitcoin got a further boost after Gary Gensler, the chair of the Securities and Exchange Commission, said Thursday he would step down in January . Gensler has pushed for more protections for crypto investors. Bitcoin and related investment have a notorious history of big price swings in both directions. MicroStrategy, a company that’s been raising cash expressly to buy bitcoin, saw an early Thursday gain of 14.6% for its stock quickly disappear. It finished the day with a loss of 16.2%. In the oil market, a barrel of benchmark U.S. crude rose 2% to bring its gain for the week to 4.8%. Brent crude, the international standard, climbed 1.8%. Oil has been rising amid escalations in the Russia-Ukraine war. In stock markets abroad, shares of India’s Adani Enterprises plunged 22.6% Thursday after the U.S. charged founder Gautam Adani in a federal indictment with securities fraud and conspiracy to commit securities and wire fraud. The businessman and one of the world’s richest people is accused of concealing that his company’s huge solar energy project on the subcontinent was being facilitated by an alleged bribery scheme. Stock indexes elsewhere in Asia and Europe were mixed. In the bond market, the yield on the 10-year Treasury inched up to 4.43% from 4.41% late Wednesday following some mixed reports on the U.S. economy. One said fewer U.S. workers applied for unemployment benefits last week in the latest signal that the job market remains solid. Another report, though, said manufacturing in the mid-Atlantic region unexpectedly shrank. Sales of previously occupied homes, meanwhile, strengthened last month by more than expected. AP Business Writers Matt Ott and Yuri Kageyama contributed.CLEVELAND, Ohio – A rivalry is renewed as the Cleveland Browns host the Pittsburgh Steelers today – Thursday, Nov. 21 – at Huntington Bank Field in Cleveland, Ohio. There are multiple free viewing options for fans who live in the Cleveland and Pittsburgh markets. Nationwide, the game can be watched at no cost through a free trial with Amazon Prime. This “Thursday Night Football” primetime matchup will kick off at 8:15 p.m. Eastern. For the Cleveland (WEWS) and Pittsburgh (WTAE) markets, there is the option to watch on Fubo (free trial and $30 off your first month) and DirecTV Stream (free trial). Sling has promotional offers as well. For out of market viewing, fans who have cut the cord on cable can catch the game at no cost exclusively on Amazon Prime Video with a free trial. The Browns (2-8) once again came out on the losing end in a Bayou battle with the New Orleans Saints in their last game, while the Steelers (8-2) notched their fifth win in a row, taking down the Baltimore Ravens in a juicy matchup atop the AFC North Division. Check out a complete rundown of NFL Week 12 action , including the schedule, predictions, previews, TV information and more. BROWNS-STEELERS Matchup Preview After suffering their seventh loss in eight games , the Browns will look for solace in an otherwise tumultuous campaign as they host the rival Steelers in what is expected be a wintry mix of conditions throughout the evening. After years of earning back respect in the rivalry , the Browns are now headed in the familiar opposite direction of Pittsburgh’s winning franchise. A season of expectations has spiraled into one of misery. With Deshaun Watson suffering a season-ending Achilles injury , quarterback Jameis Winston has stepped into the starting role, tossing for 1,047 yards, seven touchdowns and three interceptions. Often criticized for his ability to give the ball away, Winston has only had one game with a pick, which was a three-giveaway day against the Chargers' top-ranked defense. Throwing for nearly 400 yards inside the dome last week, the urge to air it out might disappear with unfavorable conditions expected to wreak havoc. The matchup is leaning more to an old-fashioned ground-and-pound style. The Browns rushing attack has been nonexistent. Nick Chubb has not returned to form and Jerome Ford has been held in check all season. Ford touts 57 carries for 279 yards and one touchdown. Chubb suffered a season-ending leg injury in the matchup against the Steelers last season. Wide receiver Cedric Tillman remains a strong threat. He has notched 27 receptions for 311 yards and three touchdowns, averaging 11.5 yards per reception. The Saints loss ended a streak of three straight games with 75 or more receiving yards. Tight end David Njoku has nabbed 39 receptions for 336 yards and two touchdowns, averaging 8.6 yards per reception. Kicker Dustin Hopkins missed three kicks , which nearly looked identical to each other, all hooking to the left. The missed opportunities didn’t make a difference in New Orleans, but in these conditions, they could be the determining factor. He also opposes the best kicker in the league this season, who is coming off a single-footed masterpiece. Reigning Defensive Player of the Year Myles Garrett has put up average numbers for his talent. He has 21 solo tackles, seven sacks and two forced fumbles. In the loss against the Saints, Garrett did not record a stat for the second time this season. Cleveland’s defense was shredded by Taysom Hill last week. The jack-of-all-trades tight end was unleashed. He notched seven carries for 138 yards and three touchdowns. While that carnage occurred on the ground, Cleveland is allowing 226.5 passing yards per game. The defense, which was the best in the NFL last season , has been known to give up explosives this year. Cleveland has only forced two interceptions this season, which is tied for second-last in the league. Three-time Pro Bowl cornerback Denzel Ward pocketed one of those last week. He has 17 solo tackles and a forced fumble also to his credit this season. With playoff aspirations seemingly out of reach, Cleveland is playing for pride. Spoiling Pittsburgh’s winning streak would be the highlight of the season. The Browns have split the last eight meetings and have been victorious in their last eight home games on “Thursday Night Football.” Watch Browns vs. Steelers on Amazon Prime Video for free The Steelers continue their stretch of four consecutive AFC North games with a rivalry stranglehold against the Browns that has loosened as of late, including a 13-10 loss last November. Pittsburgh’s offense has been a breath of fresh air for fans this season. With questions about their stagnant play coming in, the unit has silenced the critics with consistency. They have managed to score points in 22 consecutive quarters, which is the longest active streak in the NFL. Pittsburgh is led by veteran quarterback Russell Wilson , who has notched 942 yards and six touchdowns with two interceptions in four games. Wilson also has a rushing touchdown to his credit. Backup quarterback Justin Fields, who began the season under center, saw some limited play last game. Fields has notched 1,106 yards, five touchdowns and one interception. Expect the versatile playmaker to be thrown in for some packages to shake things up. Wide receiver George Pickens has gobbled up 48 receptions for 728 yards and two touchdowns, averaging 15.2 yards per reception. Tight end Pat Freiermuth has also found some spots, tallying 31 receptions for 295 yards and three touchdowns. He averages 9.5 yards per reception. Running back Jaylen Warren has been progressing, earning 64 carries for 258 yards. While those numbers may not look like much, they are an improvement from his totals in the opening games of the season. Warren also has 18 receptions for 123 yards. Kicker Chris Boswell scored all of Pittsburgh’s points in the victory over the Ravens. He is firing at a 96.7% clip and has scored an NFL-best 107 points this season. Pittsburgh’s defense resembles the Chargers unit that had a field day with Winston. The Steelers own the second-best turnover differential in the NFL at Plus-11, sitting only behind the Buffalo Bills. The defense has forced 19 takeaways and have only failed to snag an interception in three outings. Punishing linebacker T.J. Watt leads the defense with 27 solo tackles, 7.5 sacks and four forced fumbles. The Watt-Garrett comparison is one of many juicy storylines to this rivalry. Located just 130 miles apart, it’s the 146th rendition of Browns vs. Steelers in conditions that scream AFC North football. Live in Cleveland or Pittsburgh? Watch Browns vs. Steelers for free on FuboTV BROWNS-STEELERS Last Game Recap The Browns kept it competitive with the Saints until a 21-point fourth quarter while the Steelers snuck past the Ravens in a classic AFC North showdown. Cleveland Browns: Lost 35-14 to the New Orleans Saints on Nov. 17. Pittsburgh Steelers: Won 18-16 against the Baltimore Ravens on Nov. 17. BROWNS-STEELERS Players to Watch Cleveland’s playmakers will have another chance to shine in a wintry mix while Pittsburgh’s stars will look to steal the show on enemy soil. Cleveland Browns: QB Jameis Winston, DE Myles Garrett, RB Nick Chubb, K Dustin Hopkins, WR Cedric Tillman Pittsburgh Steelers: QB Russell Wilson, S Minkah Fitzpatrick, WR George Pickens, K Chris Bosworth, RB Jaylen Warren BROWNS-STEELERS Injuries of Note The Browns' offensive line took another hit this week while the Steelers remain relatively healthy for the primetime showdown. Cleveland Browns: OT Jedrick Wills Jr. (knee) and TE Geoff Swaim (concussion) are both out. QB Deshaun Watson (Achilles surgery), OT Dawand Jones (lower leg), RB Nyheim Hines (knee), LB Jeremiah Owusu-Koramoah (neck), OT James Hudson III (shoulder), LS Charley Hughlett (ribs), CB Tony Brown II, DT Michael Hall Jr. (knee) and C Nick Harris are all placed on injured reserve. Pittsburgh Steelers: LB Alex Highsmith (ankle) is out. CB Cory Trice Jr. (hamstring) and CB C.J. Henderson (neck) and WR Roman Wilson (hamstring) and defensive tackle Montravious Adams (knee) have all been placed on injured reserve. Buy Browns tickets for every game this season Who is announcing Browns vs. Steelers? Al Michaels (play-by-play) and Kirk Herbstreit (analyst) will be the announcers while Kaylee Hartung reports from the sidelines. What are the latest odds for Browns vs. Steelers? Spread: CLE: (+3.5), PIT: (-3.5) Moneyline: CLE: (+160), PIT: (-192) Point total: 37 Odds from DraftKings How to Watch BROWNS-STEELERS Who: Cleveland Browns vs. Pittsburgh Steelers When: Thursday, Nov. 21, 2024 Time: 8:15 p.m. Eastern Where: Huntington Bank Field | Cleveland, Ohio Channel: WEWS (Cleveland only), WTAE (Pittsburgh only) Best Streaming Options: Fubo (free trial and $30 off your first month), DirecTV Stream (free trial), Sling (promotional offers) and Amazon Prime Video (free trial) Channel finder if you have cable You can access the channel by using the channel finders online: Verizon Fios , AT&T U-verse , Comcast Xfinity , Spectrum/Charter , Optimum/Altice , DIRECTV and Dish . About FuboTV Fubo (free trial and $30 off your first month) has three main packages: Pro costs $79.99/month; Elite is $89.99; Premier is priced at $99.99. Cancel before the free trial ends to avoid being charged. Fubo includes access to more than 185 sports, entertainment and news channels. You can record games, TV shows, movies and more. About DirecTV Stream DirecTV Stream , which also gives customers a free trial, offers four packages if you continue with the service after your trial ends: Entertainment for $69.99; Choice for $84.99; Ultimate for $109.99; and premier for $159.99. Choice offers the most channels for sports enthusiasts. About Sling Sling , which features promotional offers for new customers, has a Blue package for $20 for your first month ($40 after that) and an Orange package for the same price and deal. Get both the Blue and Orange packages for $27.50 for your first month ($55 after that). RECOMMENDED • cleveland .com Browns vs. Saints: Watch Week 11 NFL live stream for free today Nov. 17, 2024, 6:00 a.m. Steelers vs. Browns predictions and best bets: Expect the unexpected in bad weather game Nov. 21, 2024, 2:00 p.m. About Amazon Prime Video Amazon Prime Video offers a 30-day free trial. If you’re an Amazon Prime member, this video service is included at no extra cost with your membership. Joining Amazon Prime costs $14.99/month or $139 annually. The streaming service features blockbuster movies, hit shows, Amazon Originals and sports, including select NFL games for the 2024 season. For team hats, shirts and more gear: Visit Fanatics , Dick’s Sporting Goods , Lids , Champs Sports and New Era .
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