treasures ofaztec
treasures ofaztec
(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024
NEW DELHI: Representatives of National Democratic Alliance (NDA), at their meeting at BJP president J P Nadda's residence, are said to have resolved to present a united front against the opposition's recent criticism on the BR Ambedkar issue. This meeting, held on the birth centenary of former PM Atal Bihari Vajpayee, saw an assembly of key figures including home minister Amit Shah, Andhra Pradesh CM N Chandrababu Naidu and leaders from various NDA constituents. The row erupted from what Shah described as a "doctored" version of his statement during a recent parliamentary session, which was leveraged by opposition parties to allege disrespect towards the Dalit icon. According to sources, Shah stressed the need for a coherent counter-narrative to dismantle what he termed an attempt by the opposition to create a "fake narrative". He said his statements were misrepresented and were aimed to sow discord and political unrest. A senior party functionary said, "The Ambedkar issue was integral to the discussion. It came up that Congress MPs did not react when Shah, in his speech in RS, made the remark. But later, Congress representative held a meeting where Rahul Gandhi was present and they decided to make the remark an issue to be highlighted. The way things progressed indicates Congress conspired to make Shah's comment an issue only to draw attention." Stay updated with the latest news on Times of India . Don't miss daily games like Crossword , Sudoku , Location Guesser and Mini Crossword .NEW YORK (AP) — Donald Trump used his image as a successful New York businessman to become a celebrity, a reality television star and eventually the president. Now he will get to revel in one of the most visible symbols of success in the city when he rings the opening bell of the New York Stock Exchange on Thursday as he's also named Time Magazine's Person of the Year. Trump is expected to be on Wall Street to mark the ceremonial start of the day's trading, according to four people with knowledge of his plans. He will also be announced Thursday as Time's 2024 Person of the Year , according to a person familiar with the selection. The people who confirmed the stock exchange appearance and Time award were not authorized to discuss the matter publicly and spoke to The Associated Press on condition of anonymity. It will be a notable moment of twin recognitions for Trump, a born-and-bred New Yorker who at times has treated the stock market as a measure of public approval and has long-prized signifiers of his success in New York's business world and his appearances on the covers of magazines — especially Time. Trump was named the magazine's Person of the Year in 2016, when he was first elected to the White House. He had already been listed as a finalist for this year's award alongside Vice President Kamala Harris, X owner Elon Musk, Israeli Prime Minister Benjamin Netanyahu and Kate, the Princess of Wales. Time declined to confirm the selection ahead of Thursday morning's announcement. “Time does not comment on its annual choice for Person of the Year prior to publication,” a spokesperson for the magazine said Wednesday. The ringing of the bell is a powerful symbol of U.S. capitalism — and a good New York photo opportunity at that. Despite his decades as a New York businessman, Trump has never done it before. It was unclear whether Trump, a Republican, would meet with New York's embattled mayor, Democrat Eric Adams , who has warmed to Trump and has not ruled out changing his political party. Adams has been charged with federal corruption crimes and accused of selling influence to foreign nationals; he has denied wrongdoing. Trump himself was once a symbol of New York, but he gave up living full-time in his namesake Trump Tower in Manhattan and moved to Florida after leaving the White House. CNN first reported Wednesday Trump’s visit to the stock exchange and Politico reported that Trump was expected to be unveiled as Time's Person of the Year. The stock exchange regularly invites celebrities and business leaders to participate in the ceremonial opening and closing of trading. During Trump’s first term, his wife, Melania Trump, rang the bell to promote her “Be Best” initiative on children’s well-being. Last year, Time CEO Jessica Sibley rang the opening bell to unveil the magazine's 2023 Person of the Year: Taylor Swift . After the Nov. 5 election, the S&P 500 rallied 2.5% for its best day in nearly two years. The Dow Jones Industrial Average surged 1,508 points, or 3.6%, while the Nasdaq composite jumped 3%. All three indexes topped records they had set in recent weeks. The U.S. stock market has historically tended to rise regardless of which party wins the White House, with Democrats scoring bigger average gains since 1945. But Republican control could mean big shifts in the winning and losing industries underneath the surface, and investors are adding to bets built earlier on what the higher tariffs, lower tax rates and lighter regulation that Trump favors will mean. Trump has long courted the business community based on his own status as a wealthy real estate developer who gained additional fame as the star of the TV show “The Apprentice” in which competitors tried to impress him with their business skills. He won the election in part by tapping into Americans' deep anxieties about an economy that seemed unable to meet the needs of the middle class. The larger business community has applauded his promises to reduce corporate taxes and cut regulations. But there are also concerns about his stated plans to impose broad tariffs and possibly target companies that he sees as not aligning with his own political interests. Trump spends the bulk of his time at his Florida home but was in New York for weeks this spring during his hush money trial there. He was convicted, but his lawyers are pushing for the case to be thrown out in light of his election. While he spent hours in a Manhattan courthouse every day during his criminal trial, Trump took his presidential campaign to the streets of the heavily Democratic city, holding a rally in the Bronx and popping up at settings for working-class New Yorkers: a bodega, a construction site and a firehouse. Trump returned to the city in September to meet with Ukrainian President Volodymyr Zelenskyy at his Manhattan tower and again in the final stretch of the presidential campaign when he held a rally at Madison Square Garden that drew immediate blowback as speakers made rude and racist insults and incendiary remarks . At the stock exchange, the ringing of the bell has been a tradition since the 1800s. The first guest to do it was a 10-year-old boy named Leonard Ross, in 1956, who won a quiz show answering questions about the stock market. Many times, companies listing on the exchange would ring the bell at 9:30 a.m. to commemorate their initial offerings as trading began. But the appearances have become an important marker of culture and politics -- something that Trump hopes to seize as he’s promised historic levels of economic growth. The anti-apartheid advocate and South African President Nelson Mandela rang the bell, as has Hollywood star Sylvester Stallone with his castmates from the film “The Expendables.” So, too, have the actors Robert Downey Jr. and Jeremy Renner for an “Avengers” movie and the Olympians Michael Phelps and Natalie Coughlin. In 1985, Ronald Reagan became the first sitting U.S. president to ring the bell. “With tax reform and budget control, our economy will be free to expand to its full potential, driving the bears back into permanent hibernation,” Reagan said at the time. “We’re going to turn the bull loose.” The crowd of traders on the floor chanted, “Ronnie! Ronnie! Ronnie!” The Dow Jones Industrial Average climbed in 1985 and 1986, but it suffered a decline in October 1987 in an event known as “Black Monday.” Long reported from Washington. Associated Press writer Josh Boak in Washington contributed to this report.
Watch 'Survivor' season 47 episode 13 free live stream, how to watch tonightHealth Spotlight | New method offers hope for Parkinson’s disease patients
CLEVELAND (AP) — Shortly after doing a face-down snow angel, firing a few celebratory snowballs and singing “Jingle Bells” on his way to the media room, Jameis Winston ended his postgame news conference with a simple question. “Am I a Brown yet?” he asked. He is now. And who knows? Maybe for a lot longer than expected. Winston entered Cleveland football folklore on Thursday night by leading the Browns to a 24-19 win over the division rival Pittsburgh Steelers, who had their five-game winning streak stopped. Winston’s performance at Huntington Bank Field, which transformed into the world’s largest snow globe, not only made him an instantaneous hero in the eyes of Browns fans but added another wrinkle to the team’s ever-changing, never-ending quarterback conundrum. In his fourth start since Deshaun Watson’s season-ending Achilles tendon injury, Winston made enough big plays to help the Browns (3-8) get a victory that should quiet conjecture about coach Kevin Stefanski’s job. Some wins mean more than others. In Cleveland, beating the Steelers is as big as it gets. But beyond any instant gratification, Winston has given the Browns more to consider as they move forward. RELATED COVERAGE The Ravens looked better defensively last week, but now Roquan Smith’s injury is a concern Brock Purdy will miss Sunday’s game for the 49ers with a shoulder injury Jefferson keeps seeing double as Vikings aim to stay focused on overall offensive production Watson’s future with Cleveland is highly uncertain since it will still be months before the team has a grip on whether he’s even an option in 2025, his fourth year since signing a $230 million, fully guaranteed contract that has proven calamitous. It’s also possible the Browns will cut ties with Watson. They signed Winston to a one-year contract to be Watson’s backup. But the unexpected events of 2024 have changed plans and led to the possibility that the 30-year-old Winston could become Cleveland’s full-time QB or a bridge to their next young one. The AP Top 25 college football poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . So much is unclear. What’s not is that Winston, who leaped into the end zone on fourth-and-2 for a TD to put the Browns ahead 18-6 in the fourth quarter, is a difference maker. With his larger-than-life personality and the joy he shows whether practicing or throwing three touchdown passes, he has lifted the Browns. A man of faith, he’s made his teammates believe. Winston has done what Watson couldn’t: made the Browns better. “A very, very authentic person,” Stefanski said Friday on a Zoom call. “He’s the same guy every single day. He’s the same guy at 5 a.m. as he at 5 p.m. He brings great energy to everything he does, and I think his teammates appreciate that about him.” Winston, who is 2-2 as a starter with wins over the Steelers and Baltimore Ravens, has a knack for inspiring through fiery, preacher-like pregame speeches. But what has impressed the Browns is his ability to stay calm in the storm. “He doesn’t get rattled,” said Myles Garrett, who had three sacks against the Steelers . “He’s just tuned in and focused as anyone I’ve seen at that position. Turn the page. There was a turnover, came back to the sideline, ‘Love you. I’m sorry. We’re going to get it back.’ He was already on to the next one, ‘How can we complete the mission?’ “I have a lot of respect for him. First was from afar and now seeing it on the field in front of me, it’s a blessing to have someone who plays a game with such a passion and want-to. You can’t ask for a better teammate when they take those things to heart and they want to play for you like we’re actually brothers and that’s what we have to attain. That brotherhood.” What’s working Winston has done something else Watson couldn’t: move the offense. The Browns scored more than 20 points for just the second time this season, and like Joe Flacco a year ago, Winston has shown that Stefanski’s system works with a quarterback patient enough to let plays develop and unafraid to take shots downfield. What needs help The conditions certainly were a factor, but the Browns were a miserable 1 of 10 on third down, a season-long trend. However, Cleveland converted all four fourth-down tries, including a fourth-and-3 pass from Winston to Jerry Jeudy with 2:36 left that helped set up Nick Chubb’s go-ahead TD run. Stock up RT Jack Conklin. Garrett outplayed Steelers star T.J. Watt in their rivalry within the rivalry partly because Conklin did a nice job containing Pittsburgh’s edge rusher, who was held without a sack and had one tackle for loss. Conklin has made a remarkable comeback since undergoing reconstructive knee surgery last year. Stock down Owners Dee and Jimmy Haslam. Their desire to build a dome is well intended, but an indoor game could never come close to matching the surreal setting of Thursday night, when snow swirled throughout the stadium and covered nearly all the yard lines and hash marks. “It was beautiful,” Winston said. Injuries WR Cedric Tillman is in the concussion protocol. He had two catches before taking a big hit on the final play of the third quarter. Key numbers 9 — Consecutive home wins for the Browns in Thursday night games. Three of those have come against Pittsburgh. What’s next An extended break before visiting the Denver Broncos on Dec. 2. ___ AP NFL: https://apnews.com/hub/NFLZURICH (AP) — Saudi Arabia scored a major win in its campaign to attract major sports events to the kingdom when it was formally on Wednesday. Still, many questions remain about the tournament as well as the 2030 World Cup, which will be co-hosted by Spain, Portugal and Morocco, with three games in South America. Here are some of the key issues that need to be answered over the next decade: Where will games be played? Saudi Arabia proposes 15 stadiums — eight still on paper — in five cities: Eight in the capital Riyadh, four in the Red Sea port city Jeddah, and one each in Abha, Al Khobar and Neom, the planned futuristic mega-project. Each would have at least 40,000 seats for World Cup games. The opening game and final are set for a 92,000-seat venue planned in Riyadh. Some designs are . In Neom, the stadium is planned 350 meters (yards) above street level and is designed to be atop a 200-meter cliff with a retractable wall of LED screens. Saudi Arabia aims to host all 104 games, though there has been speculation that some games could be played in neighboring or nearby countries. When will the World Cup be played? Surely not in the traditional World Cup period of June-July, when temperatures in Saudi Arabia routinely exceed 40 Celsius (104 degrees). FIFA moved the Qatar-hosted World Cup to November-December 2022, though those dates were not loved by most European clubs and leagues whose seasons were interrupted. Also, that slot is complicated in 2034 by the holy month of Ramadan through mid-December and Riyadh hosting the multi-sport Asian Games. January 2034 could be a possibility even though that would be just before the Winter Olympics in Salt Lake City. The it won’t be opposed to back-to-back major events. In an interview with The Associated Press on Wednesday, Saudi World Cup bid official Hammad Albalawi said the precise dates of the tournament are up the world soccer body. “That’s a decision by FIFA. We stand ready to be part of this conversation. But ultimately it’s a FIFA decision together with the confederations,” Albalawi said. Will stadiums be segregated for men and women? Giving more rights and freedoms to women in a traditionally conservative society is fundamental to Saudi messaging around the modernization program known as Vision 2030. The kingdom to let women attend sports events, initially in major cities and separate from men-only sections. By 2034, at the promised pace of social reforms, female fans should not be restricted. Saudi Arabia launched a women’s professional soccer league in 2022 with players joining from clubs in Europe. They face no restrictions playing in shorts and with hair uncovered. Will alcohol be allowed at the venues or hotels? The Saudi prohibition of alcohol is clear and understood before FIFA signs any sponsor deals for 2034. But will there be any exceptions? The alcohol issue was problematic for the World Cup in Qatar because the expectation was created that beer sales would be allowed at stadiums even before Qatar won its bid in 2010. One year later, FIFA extended a long-time deal to have Budweiser as the official World Cup beer through 2022. Qatar then backtracked on that promise three days before the first game, causing confusion and the sense of a promise broken. In Qatar, alcohol was served only at luxury suites at the stadiums. Visitors could also have a drink in some hotel bars. But Saudi Arabia has even stricter rules on alcohol — and there is no indication that will change. Albalawi noted that Saudi Arabia has successfully hosted dozens of sports events where alcohol wasn’t served. “We’re creating a safe and secure family environment for fans to bring their families into our stadiums,” he said. How will workers rights be protected? Saudi promises to reform and enforce labor laws, and fully respect migrant workers, have been accepted by FIFA but face and trade unions. A by the U.N.-backed International Labor Organization. Protecting the migrant workers needed to build stadiums and other tournament projects — a decade after it was a defining issue for Qatar — looms as a signature challenge for Saudi Arabia. Would Israel be allowed to play if it qualified for the 2034 World Cup? had been improving when FIFA all but gave the 2034 World Cup to the kingdom on Oct. 4 last year. Three days later Hamas attacked Israel and diplomacy got more complicated. Any soccer federation bidding to host a FIFA tournament accepts a basic principle that whichever team qualifies is welcome. That did not stop Indonesia putting up barriers last year to Israel coming for the men’s Under-20 World Cup. Indonesia does not have formal diplomatic relations with Israel which had qualified through a European tournament nine months before FIFA moved the entire tournament to Argentina and the Israeli team reached the semifinals. Israel played at the 1970 World Cup but has never advanced through qualifying in Europe, where it has been a member of UEFA for 30 years. Europe should have 16 places in the 48-team World Cup in Saudi Arabia. Where will the final of the 2030 World Cup be played? Most of the attention at the FIFA Congress on Wednesday was on the Saudi decision, but the soccer body and its members also formally approved the hosts of the 2030 World Cup — the most spread out and longest ever. One game each in Argentina, Paraguay and Uruguay, the original host in 1930, will be played from June 8-9. The tournament resumes four days later for the other 101 games shared between Spain, Portugal and Morocco. Six countries, three continents, multiple languages and currencies. Fans traveling on planes, trains, automobiles and boats across about 14 kilometers (10 miles) of water between Spain and Morocco. The final is due on July 21, 2030 and a decision on where it will be played could cause some tension between the host countries. Morocco wants it in the world’s biggest soccer venue — the planned 115,000-seat King Hassan II Stadium in Casablanca. Spain, meanwhile, has proposed to host the final in either of the remodeled home stadiums of club giants Real Madrid or Barcelona. ___ Associated Press writer Baraa Anwer in Riyadh, Saudi Arabia, contributed to this report. Graham Dunbar, The Associated PressThe most startup-friendly countries in 2024
treasures ofaztec
(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024
NEW DELHI: Representatives of National Democratic Alliance (NDA), at their meeting at BJP president J P Nadda's residence, are said to have resolved to present a united front against the opposition's recent criticism on the BR Ambedkar issue. This meeting, held on the birth centenary of former PM Atal Bihari Vajpayee, saw an assembly of key figures including home minister Amit Shah, Andhra Pradesh CM N Chandrababu Naidu and leaders from various NDA constituents. The row erupted from what Shah described as a "doctored" version of his statement during a recent parliamentary session, which was leveraged by opposition parties to allege disrespect towards the Dalit icon. According to sources, Shah stressed the need for a coherent counter-narrative to dismantle what he termed an attempt by the opposition to create a "fake narrative". He said his statements were misrepresented and were aimed to sow discord and political unrest. A senior party functionary said, "The Ambedkar issue was integral to the discussion. It came up that Congress MPs did not react when Shah, in his speech in RS, made the remark. But later, Congress representative held a meeting where Rahul Gandhi was present and they decided to make the remark an issue to be highlighted. The way things progressed indicates Congress conspired to make Shah's comment an issue only to draw attention." Stay updated with the latest news on Times of India . Don't miss daily games like Crossword , Sudoku , Location Guesser and Mini Crossword .NEW YORK (AP) — Donald Trump used his image as a successful New York businessman to become a celebrity, a reality television star and eventually the president. Now he will get to revel in one of the most visible symbols of success in the city when he rings the opening bell of the New York Stock Exchange on Thursday as he's also named Time Magazine's Person of the Year. Trump is expected to be on Wall Street to mark the ceremonial start of the day's trading, according to four people with knowledge of his plans. He will also be announced Thursday as Time's 2024 Person of the Year , according to a person familiar with the selection. The people who confirmed the stock exchange appearance and Time award were not authorized to discuss the matter publicly and spoke to The Associated Press on condition of anonymity. It will be a notable moment of twin recognitions for Trump, a born-and-bred New Yorker who at times has treated the stock market as a measure of public approval and has long-prized signifiers of his success in New York's business world and his appearances on the covers of magazines — especially Time. Trump was named the magazine's Person of the Year in 2016, when he was first elected to the White House. He had already been listed as a finalist for this year's award alongside Vice President Kamala Harris, X owner Elon Musk, Israeli Prime Minister Benjamin Netanyahu and Kate, the Princess of Wales. Time declined to confirm the selection ahead of Thursday morning's announcement. “Time does not comment on its annual choice for Person of the Year prior to publication,” a spokesperson for the magazine said Wednesday. The ringing of the bell is a powerful symbol of U.S. capitalism — and a good New York photo opportunity at that. Despite his decades as a New York businessman, Trump has never done it before. It was unclear whether Trump, a Republican, would meet with New York's embattled mayor, Democrat Eric Adams , who has warmed to Trump and has not ruled out changing his political party. Adams has been charged with federal corruption crimes and accused of selling influence to foreign nationals; he has denied wrongdoing. Trump himself was once a symbol of New York, but he gave up living full-time in his namesake Trump Tower in Manhattan and moved to Florida after leaving the White House. CNN first reported Wednesday Trump’s visit to the stock exchange and Politico reported that Trump was expected to be unveiled as Time's Person of the Year. The stock exchange regularly invites celebrities and business leaders to participate in the ceremonial opening and closing of trading. During Trump’s first term, his wife, Melania Trump, rang the bell to promote her “Be Best” initiative on children’s well-being. Last year, Time CEO Jessica Sibley rang the opening bell to unveil the magazine's 2023 Person of the Year: Taylor Swift . After the Nov. 5 election, the S&P 500 rallied 2.5% for its best day in nearly two years. The Dow Jones Industrial Average surged 1,508 points, or 3.6%, while the Nasdaq composite jumped 3%. All three indexes topped records they had set in recent weeks. The U.S. stock market has historically tended to rise regardless of which party wins the White House, with Democrats scoring bigger average gains since 1945. But Republican control could mean big shifts in the winning and losing industries underneath the surface, and investors are adding to bets built earlier on what the higher tariffs, lower tax rates and lighter regulation that Trump favors will mean. Trump has long courted the business community based on his own status as a wealthy real estate developer who gained additional fame as the star of the TV show “The Apprentice” in which competitors tried to impress him with their business skills. He won the election in part by tapping into Americans' deep anxieties about an economy that seemed unable to meet the needs of the middle class. The larger business community has applauded his promises to reduce corporate taxes and cut regulations. But there are also concerns about his stated plans to impose broad tariffs and possibly target companies that he sees as not aligning with his own political interests. Trump spends the bulk of his time at his Florida home but was in New York for weeks this spring during his hush money trial there. He was convicted, but his lawyers are pushing for the case to be thrown out in light of his election. While he spent hours in a Manhattan courthouse every day during his criminal trial, Trump took his presidential campaign to the streets of the heavily Democratic city, holding a rally in the Bronx and popping up at settings for working-class New Yorkers: a bodega, a construction site and a firehouse. Trump returned to the city in September to meet with Ukrainian President Volodymyr Zelenskyy at his Manhattan tower and again in the final stretch of the presidential campaign when he held a rally at Madison Square Garden that drew immediate blowback as speakers made rude and racist insults and incendiary remarks . At the stock exchange, the ringing of the bell has been a tradition since the 1800s. The first guest to do it was a 10-year-old boy named Leonard Ross, in 1956, who won a quiz show answering questions about the stock market. Many times, companies listing on the exchange would ring the bell at 9:30 a.m. to commemorate their initial offerings as trading began. But the appearances have become an important marker of culture and politics -- something that Trump hopes to seize as he’s promised historic levels of economic growth. The anti-apartheid advocate and South African President Nelson Mandela rang the bell, as has Hollywood star Sylvester Stallone with his castmates from the film “The Expendables.” So, too, have the actors Robert Downey Jr. and Jeremy Renner for an “Avengers” movie and the Olympians Michael Phelps and Natalie Coughlin. In 1985, Ronald Reagan became the first sitting U.S. president to ring the bell. “With tax reform and budget control, our economy will be free to expand to its full potential, driving the bears back into permanent hibernation,” Reagan said at the time. “We’re going to turn the bull loose.” The crowd of traders on the floor chanted, “Ronnie! Ronnie! Ronnie!” The Dow Jones Industrial Average climbed in 1985 and 1986, but it suffered a decline in October 1987 in an event known as “Black Monday.” Long reported from Washington. Associated Press writer Josh Boak in Washington contributed to this report.
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CLEVELAND (AP) — Shortly after doing a face-down snow angel, firing a few celebratory snowballs and singing “Jingle Bells” on his way to the media room, Jameis Winston ended his postgame news conference with a simple question. “Am I a Brown yet?” he asked. He is now. And who knows? Maybe for a lot longer than expected. Winston entered Cleveland football folklore on Thursday night by leading the Browns to a 24-19 win over the division rival Pittsburgh Steelers, who had their five-game winning streak stopped. Winston’s performance at Huntington Bank Field, which transformed into the world’s largest snow globe, not only made him an instantaneous hero in the eyes of Browns fans but added another wrinkle to the team’s ever-changing, never-ending quarterback conundrum. In his fourth start since Deshaun Watson’s season-ending Achilles tendon injury, Winston made enough big plays to help the Browns (3-8) get a victory that should quiet conjecture about coach Kevin Stefanski’s job. Some wins mean more than others. In Cleveland, beating the Steelers is as big as it gets. But beyond any instant gratification, Winston has given the Browns more to consider as they move forward. RELATED COVERAGE The Ravens looked better defensively last week, but now Roquan Smith’s injury is a concern Brock Purdy will miss Sunday’s game for the 49ers with a shoulder injury Jefferson keeps seeing double as Vikings aim to stay focused on overall offensive production Watson’s future with Cleveland is highly uncertain since it will still be months before the team has a grip on whether he’s even an option in 2025, his fourth year since signing a $230 million, fully guaranteed contract that has proven calamitous. It’s also possible the Browns will cut ties with Watson. They signed Winston to a one-year contract to be Watson’s backup. But the unexpected events of 2024 have changed plans and led to the possibility that the 30-year-old Winston could become Cleveland’s full-time QB or a bridge to their next young one. The AP Top 25 college football poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . So much is unclear. What’s not is that Winston, who leaped into the end zone on fourth-and-2 for a TD to put the Browns ahead 18-6 in the fourth quarter, is a difference maker. With his larger-than-life personality and the joy he shows whether practicing or throwing three touchdown passes, he has lifted the Browns. A man of faith, he’s made his teammates believe. Winston has done what Watson couldn’t: made the Browns better. “A very, very authentic person,” Stefanski said Friday on a Zoom call. “He’s the same guy every single day. He’s the same guy at 5 a.m. as he at 5 p.m. He brings great energy to everything he does, and I think his teammates appreciate that about him.” Winston, who is 2-2 as a starter with wins over the Steelers and Baltimore Ravens, has a knack for inspiring through fiery, preacher-like pregame speeches. But what has impressed the Browns is his ability to stay calm in the storm. “He doesn’t get rattled,” said Myles Garrett, who had three sacks against the Steelers . “He’s just tuned in and focused as anyone I’ve seen at that position. Turn the page. There was a turnover, came back to the sideline, ‘Love you. I’m sorry. We’re going to get it back.’ He was already on to the next one, ‘How can we complete the mission?’ “I have a lot of respect for him. First was from afar and now seeing it on the field in front of me, it’s a blessing to have someone who plays a game with such a passion and want-to. You can’t ask for a better teammate when they take those things to heart and they want to play for you like we’re actually brothers and that’s what we have to attain. That brotherhood.” What’s working Winston has done something else Watson couldn’t: move the offense. The Browns scored more than 20 points for just the second time this season, and like Joe Flacco a year ago, Winston has shown that Stefanski’s system works with a quarterback patient enough to let plays develop and unafraid to take shots downfield. What needs help The conditions certainly were a factor, but the Browns were a miserable 1 of 10 on third down, a season-long trend. However, Cleveland converted all four fourth-down tries, including a fourth-and-3 pass from Winston to Jerry Jeudy with 2:36 left that helped set up Nick Chubb’s go-ahead TD run. Stock up RT Jack Conklin. Garrett outplayed Steelers star T.J. Watt in their rivalry within the rivalry partly because Conklin did a nice job containing Pittsburgh’s edge rusher, who was held without a sack and had one tackle for loss. Conklin has made a remarkable comeback since undergoing reconstructive knee surgery last year. Stock down Owners Dee and Jimmy Haslam. Their desire to build a dome is well intended, but an indoor game could never come close to matching the surreal setting of Thursday night, when snow swirled throughout the stadium and covered nearly all the yard lines and hash marks. “It was beautiful,” Winston said. Injuries WR Cedric Tillman is in the concussion protocol. He had two catches before taking a big hit on the final play of the third quarter. Key numbers 9 — Consecutive home wins for the Browns in Thursday night games. Three of those have come against Pittsburgh. What’s next An extended break before visiting the Denver Broncos on Dec. 2. ___ AP NFL: https://apnews.com/hub/NFLZURICH (AP) — Saudi Arabia scored a major win in its campaign to attract major sports events to the kingdom when it was formally on Wednesday. Still, many questions remain about the tournament as well as the 2030 World Cup, which will be co-hosted by Spain, Portugal and Morocco, with three games in South America. Here are some of the key issues that need to be answered over the next decade: Where will games be played? Saudi Arabia proposes 15 stadiums — eight still on paper — in five cities: Eight in the capital Riyadh, four in the Red Sea port city Jeddah, and one each in Abha, Al Khobar and Neom, the planned futuristic mega-project. Each would have at least 40,000 seats for World Cup games. The opening game and final are set for a 92,000-seat venue planned in Riyadh. Some designs are . In Neom, the stadium is planned 350 meters (yards) above street level and is designed to be atop a 200-meter cliff with a retractable wall of LED screens. Saudi Arabia aims to host all 104 games, though there has been speculation that some games could be played in neighboring or nearby countries. When will the World Cup be played? Surely not in the traditional World Cup period of June-July, when temperatures in Saudi Arabia routinely exceed 40 Celsius (104 degrees). FIFA moved the Qatar-hosted World Cup to November-December 2022, though those dates were not loved by most European clubs and leagues whose seasons were interrupted. Also, that slot is complicated in 2034 by the holy month of Ramadan through mid-December and Riyadh hosting the multi-sport Asian Games. January 2034 could be a possibility even though that would be just before the Winter Olympics in Salt Lake City. The it won’t be opposed to back-to-back major events. In an interview with The Associated Press on Wednesday, Saudi World Cup bid official Hammad Albalawi said the precise dates of the tournament are up the world soccer body. “That’s a decision by FIFA. We stand ready to be part of this conversation. But ultimately it’s a FIFA decision together with the confederations,” Albalawi said. Will stadiums be segregated for men and women? Giving more rights and freedoms to women in a traditionally conservative society is fundamental to Saudi messaging around the modernization program known as Vision 2030. The kingdom to let women attend sports events, initially in major cities and separate from men-only sections. By 2034, at the promised pace of social reforms, female fans should not be restricted. Saudi Arabia launched a women’s professional soccer league in 2022 with players joining from clubs in Europe. They face no restrictions playing in shorts and with hair uncovered. Will alcohol be allowed at the venues or hotels? The Saudi prohibition of alcohol is clear and understood before FIFA signs any sponsor deals for 2034. But will there be any exceptions? The alcohol issue was problematic for the World Cup in Qatar because the expectation was created that beer sales would be allowed at stadiums even before Qatar won its bid in 2010. One year later, FIFA extended a long-time deal to have Budweiser as the official World Cup beer through 2022. Qatar then backtracked on that promise three days before the first game, causing confusion and the sense of a promise broken. In Qatar, alcohol was served only at luxury suites at the stadiums. Visitors could also have a drink in some hotel bars. But Saudi Arabia has even stricter rules on alcohol — and there is no indication that will change. Albalawi noted that Saudi Arabia has successfully hosted dozens of sports events where alcohol wasn’t served. “We’re creating a safe and secure family environment for fans to bring their families into our stadiums,” he said. How will workers rights be protected? Saudi promises to reform and enforce labor laws, and fully respect migrant workers, have been accepted by FIFA but face and trade unions. A by the U.N.-backed International Labor Organization. Protecting the migrant workers needed to build stadiums and other tournament projects — a decade after it was a defining issue for Qatar — looms as a signature challenge for Saudi Arabia. Would Israel be allowed to play if it qualified for the 2034 World Cup? had been improving when FIFA all but gave the 2034 World Cup to the kingdom on Oct. 4 last year. Three days later Hamas attacked Israel and diplomacy got more complicated. Any soccer federation bidding to host a FIFA tournament accepts a basic principle that whichever team qualifies is welcome. That did not stop Indonesia putting up barriers last year to Israel coming for the men’s Under-20 World Cup. Indonesia does not have formal diplomatic relations with Israel which had qualified through a European tournament nine months before FIFA moved the entire tournament to Argentina and the Israeli team reached the semifinals. Israel played at the 1970 World Cup but has never advanced through qualifying in Europe, where it has been a member of UEFA for 30 years. Europe should have 16 places in the 48-team World Cup in Saudi Arabia. Where will the final of the 2030 World Cup be played? Most of the attention at the FIFA Congress on Wednesday was on the Saudi decision, but the soccer body and its members also formally approved the hosts of the 2030 World Cup — the most spread out and longest ever. One game each in Argentina, Paraguay and Uruguay, the original host in 1930, will be played from June 8-9. The tournament resumes four days later for the other 101 games shared between Spain, Portugal and Morocco. Six countries, three continents, multiple languages and currencies. Fans traveling on planes, trains, automobiles and boats across about 14 kilometers (10 miles) of water between Spain and Morocco. The final is due on July 21, 2030 and a decision on where it will be played could cause some tension between the host countries. Morocco wants it in the world’s biggest soccer venue — the planned 115,000-seat King Hassan II Stadium in Casablanca. Spain, meanwhile, has proposed to host the final in either of the remodeled home stadiums of club giants Real Madrid or Barcelona. ___ Associated Press writer Baraa Anwer in Riyadh, Saudi Arabia, contributed to this report. Graham Dunbar, The Associated PressThe most startup-friendly countries in 2024
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