jilipark vip

FNA Deadline: FNA Investors with Losses in Excess of $100K Have Opportunity to Lead Paragon 28, Inc. Securities Fraud Lawsuit First Filed by The Rosen Law FirmIntuitive Surgical Inc. stock outperforms competitors on strong trading day

The results from their first-in-human study demonstrated that median overall survival was doubled and progression-free survival improved 3-fold The Company's novel sonodynamic therapy platform selectively targets and destroys cancer cells in the brain while preserving healthy tissue CHANHASSEN, Minn. , Nov. 24, 2024 /PRNewswire/ -- Alpheus Medical, Inc., a private, clinical-stage oncology company pioneering sonodynamic therapy (SDT) for the treatment of solid body cancers, today announced positive results from their Phase 1/2 clinical trial in patients with recurrent or refractory high-grade gliomas. The company's proprietary therapy demonstrated a strong safety profile and extended median overall survival (OS) and progression-free survival (PFS) compared to historical data. The data were presented by Michael Schulder , MD, at the 2024 Society of Neuro-Oncology (SNO) Annual Meeting. "Glioblastomas are the most common and aggressive primary brain cancer, presenting a devasting diagnosis for patients and their familes," said David Reardon , MD, Clinical Director of the Center for Neuro-Oncology at Dana-Farber Cancer Institute, and member of the Alpheus Medical Scientific Advisory Board. "Current treatment options are limited and often ineffective due to the diffuse spread of the disease across the blood-brain barrier and often across the entire hemisphere, making it universally fatal with a rapid timeline. The early clinical results of Alpheus's therapy are promising, offering hope for this new approach. I look forward to further exploring the potential benefits of their SDT therapy for this patient population who is in critical need of an effective solution." Alpheus Medical's non-invasive SDT treatment, which can be delivered in an outpatient setting, combines low-intensity diffuse ultrasound (LIDU TM ) with oral 5-aminolevulinic acid (5-ALA) to target and kill cancer cells across the entire hemisphere without the need for imaging or sedation. Key findings from the study include: Median overall survival (OS): 15.7 months vs. historical ~6-8 months Median progression-free survival (PFS): 5.5 months vs. historical 1.8 month Safety: No treatment-related deaths, serious adverse events (SAEs), or duration-limited toxicities (DuLTs) reported "In addition to the strong safety data and early indications of efficacy, Alpheus' non-invasive SDT therapy stands out for its ease of use - a significant improvement over the uncomfortable and often toxic treatments currently available for this rapidly fatal condition," stated Dr. Schulder, Director of the Brain Tumor Center at Northwell Health, and one of the trial's primary investigators. "We look forward to expanding the ability for patients to receive this promising therapy." The Phase 1/2 trial ( NCT05362409 ) is an open-label, multicenter, duration-escalation study evaluating the safety, optimal dose, and efficacy of Alpheus Medical's proprietary SDT platform. Twelve patients were enrolled across three cohorts, with treatment durations escalating to 60, 90, and 120 minutes per monthly session. The company plans to initiate a randomized, controlled trial at multiple centers across the U.S. in 2025. About Alpheus Medical, Inc. Alpheus Medical is a private, clinical-stage oncology company revolutionizing the treatment of solid body cancers with its pioneering sonodynamic therapy (SDT) platform that combines Low-Intensity Diffuse Ultrasound (LIDU TM ) with the sensitizing agent, oral 5-aminolevulinic acid (5-ALA). The company's proprietary, non-invasive technology is designed to selectively target and destroy cancer cells in the brain while preserving healthy tissue. Learn more at www.alpheusmedical.com . Media Contact Carla Benigni carla@sprigconsulting.com View original content to download multimedia: https://www.prnewswire.com/news-releases/alpheus-medical-announces-positive-phase-12-trial-results-for-the-treatment-of-recurrent-high-grade-gliomas-302314785.html SOURCE Alpheus Medical

Step Into Notre Dame Cathedral Through AR Ahead Of Its Grand ReopeningElon Musk threatened to buy MSNBC. Joe Rogan jumped in with ideas, too.The Associated Press article “Hamas, Fatah near a deal on who will oversee postwar Gaza” (Dec. 4, 2024) presents a post-war Gaza that assures another Hamas attack. First, Hamas and Fatah are active terrorist organizations that can’t be considered “politically independent technocrats.” Hamas is a U.S. designated terrorist entity. While Fatah is put forward as the moderating force, that is ludicrous in light of its “pay-to-slay” program – a several hundred million dollar budget item to pay terrorists who kill Jews and to support terrorists’ families. Second, a Hamas/Fatah government would perpetuate the same leaders who plotted and executed the Oct. 7, 2023 atrocities. A Hamas/Fatah government also gives Hamas and Fatah control of all the global resources necessary to stabilize and redevelop Gaza. Since 1948 the world has spent billions of dollars in Gaza. That investment funded construction of an imposing network of terror tunnels and grew the crop of Hamas fighters and Gazan civilians who slaughtered 1200 Israelis and foreigners on Oct. 7. The world, including Gazans themselves, deserve a professional, truly independent government committed to Gaza’s citizens and to peace, not to the same corruption and depravity. Elaine Albom Braffman, Esq. Woodbridge

The Associated Press article “Hamas, Fatah near a deal on who will oversee postwar Gaza” (Dec. 4, 2024) presents a post-war Gaza that assures another Hamas attack. First, Hamas and Fatah are active terrorist organizations that can’t be considered “politically independent technocrats.” Hamas is a U.S. designated terrorist entity. While Fatah is put forward as the moderating force, that is ludicrous in light of its “pay-to-slay” program – a several hundred million dollar budget item to pay terrorists who kill Jews and to support terrorists’ families. Second, a Hamas/Fatah government would perpetuate the same leaders who plotted and executed the Oct. 7, 2023 atrocities. A Hamas/Fatah government also gives Hamas and Fatah control of all the global resources necessary to stabilize and redevelop Gaza. Since 1948 the world has spent billions of dollars in Gaza. That investment funded construction of an imposing network of terror tunnels and grew the crop of Hamas fighters and Gazan civilians who slaughtered 1200 Israelis and foreigners on Oct. 7. The world, including Gazans themselves, deserve a professional, truly independent government committed to Gaza’s citizens and to peace, not to the same corruption and depravity. Elaine Albom Braffman, Esq. WoodbridgeAuthored by Austin Alonzo via The Epoch Times (emphasis ours), Although President-elect Donald Trump and the Republican Party swept the 2024 general election, the cryptocurrency industry feels it is the real winner. Powered by donations from some of the biggest figures in cryptocurrency and venture capital, three political action committees poured more than $100 million into efforts to influence the 2024 election. “ This election was a huge win for crypto ,” co-founder and CEO of Coinbase Global Inc. Brian Armstrong wrote on Nov. 7 in an article on X. Coinbase, a cryptocurrency exchange founded in 2012, donated about $55 million to the super PAC Fairshake, according to Federal Election Commission records. Armstrong personally donated $1 million. As Armstrong wrote, the industry had much to celebrate in early November. It saw its preferred candidates take the White House and win key seats in both houses of Congress. He declared that the 119th Congress will be the “most pro-crypto Congress ever.” In his message, Coinbase’s leader wrote something that is usually implied but rarely said in the world of political spending, too. “ [Washington] received a clear message that being anti-crypto is a good way to end your career ,” Armstrong said. Twenty years ago, few people had heard of cryptocurrency—a term used to refer to decentralized digital currencies as opposed to central bank digital currencies (CBDCs) that are controlled and backed by a government or central bank. One week after the Nov. 5 election, a Bitcoin was trading for more than $89,000. Gold, by comparison, traded for about $2,600 an ounce on the same day. Between 2007 and 2009, a person or group known as Satoshi Nakamoto conceived of and launched Bitcoin . It was a new type of digital money secured via encryption technology. Unlike traditional currency, Bitcoin can transfer value online without a bank or a payment processor. It is not backed by any government, central bank fiat currency, or physical asset. Bitcoin began as an obscure novelty worth less than 10 cents per token. However, its price has exploded in the last decade, creating significant public interest in the digital asset. According to the crypto website Coinranking, as of Nov. 13, Bitcoin’s market capitalization was about $1.83 trillion. Nevertheless, public opinion polling shows that a majority of Americans are not confident in cryptocurrency as an investment. A Pew Research Center study published in October found that just 5 percent of the people it surveyed in February said they were “very” or “extremely” confident in the reliability and safety of cryptocurrency. The same report found that 17 percent of Americans have ever invested in, traded, or used a cryptocurrency. As an investment, about 38 percent of respondents said cryptocurrency has done “worse than expected.” Rick Claypool, the research director in the president’s office of Public Citizen, told The Epoch Times that cryptocurrency, generally, is an extremely volatile investment vehicle without any intrinsic value—one that is now very risky for the average investor. Public Citizen, founded in 1971, is a nonprofit consumer advocacy organization. In May, it published a report describing the cryptocurrency industry’s investment in politics as part of a “strategy of combating enforcement crackdowns and designing a regulatory system that meets the industry’s specifications.” The growing use of cryptocurrency over the last decade, and concern about the consumer risks, has led to a rush to begin regulating the fast-growing industry. The swift rise and fall of Sam Bankman-Fried and his cryptocurrency exchange FTX highlighted the potential for fraud in a lightly regulated sector of the economy. In March, Bankman-Fried was sentenced to 25 years in prison and ordered to pay $11 billion in forfeiture for what the U.S. Department of Justice called his “orchestration of multiple fraudulent schemes.” Bankman-Fried was accused of stealing more than $8 billion of his customer’s money through FTX and Alameda Research, a cryptocurrency trading firm he founded. Bankman-Fried was initially arrested in the Bahamas and extradited to the United States, where he was charged with multiple fraud offenses, in December 2022. FTX collapsed in November 2022. A year earlier, Securities and Exchange Commission chairman Gary Gensler asked the Senate’s Banking Housing and Urban Affairs Committee for additional resources to begin addressing regulatory concerns surrounding the cryptocurrency industry. In that testimony, he said the entire crypto asset class was “rife with fraud, scams, and abuse.” Under Gensler, who was appointed commissioner by President Joe Biden in April 2021, the SEC views most crypto assets as securities. Since 2022, the SEC has charged multiple firms with violating federal securities law by offering and selling unregistered securities. As recently as Oct. 9, when he appeared at a conference at the New York University School of Law, Gensler said he continues to view the crypto industry as a hotbed of “fraudsters,” “grifters,” and “scams.” Gensler’s actions made him the crypto industry’s top political enemy , Claypool said. In 2024, the industry began spending on political causes through three linked committees: Fairshake, Defend American Jobs, and Protect Progress. Claypool said while these PACs were founded and funded by crypto, none of the advertisements and political messaging they paid for said anything about cryptocurrency or a candidate’s positions on financial regulations. Fairshake was launched in May 2023. According to federal records, within its first six months, it received donations of $1 million or more from Armstrong, Coinbase, and venture capital firm Andreessen Horowitz’s co-founders Marc Andreessen and Ben Horowitz. By the end of 2023, it had raised about $85.7 million. Representatives of Coinbase, Andreessen, and Horowitz did not respond to a request for comment from The Epoch Times. According to its latest FEC disclosure, covering its activities through Oct. 16, the PAC raised about $118.4 million and spent about $153.3 million in 2024. Its top donors were Coinbase, executives at Andreessen Horowitz, and Ripple Labs Inc. Representatives of Ripple did not respond to a request for comment from The Epoch Times. Fairshake’s most significant independent expenditures against a single candidate, totaling more than $10 million, went toward opposing Rep. Katie Porter (D-Calif.) in her bid to replace outgoing Sen. Laphonza Butler (D-Calif.). Porter lost in the state’s Democratic Party primary to Senator-elect Adam Schiff (D-Calif.) in March. Ahead of Porter’s primary, a new political group called the Stand With Crypto Alliance emerged. In its inaugural release, dated Feb. 7, Stand With Crypto said it planned to launch a “candidate questionnaire and voter education program” in California. Read the rest here...

None

(adsbygoogle = window.adsbygoogle || []).push({}); Protecting sensitive data nowadays should be a top priority for businesses of all sizes. Data breaches and cyber threats are no longer occasional occurrences but constant risks that require ongoing attention. The global cost of cyberattacks is expected to hit $9.5 trillion in 2024, largely fueled by ransomware, phishing, and data breaches. To combat these threats, companies need robust, continuous security measures that adapt as threats evolve. Traditional security measures, while effective to an extent, often involve manual processes that can be inconsistent, leaving gaps in protection. Automation is changing the landscape as it allows businesses to protect data more effectively through real-time encryption and automated security audits. Automating data security processes means sensitive information is consistently protected, and security status is constantly monitored without relying solely on human effort. Automation, combined with other technologies like machine learning, offers businesses the ability to stay one step ahead. Let’s discuss more on this below: Using Robotic Process Automation Robotic process automation (RPA) has become a valuable tool in automating repetitive tasks across various business functions, and data security is no exception. RPA can handle tasks such as data encryption, access control management, and audit preparation, which are critical in maintaining a secure data environment. Thanks to RPA, businesses can create automated workflows that perform these tasks quickly and consistently, eliminating human error and freeing up security teams to focus on more complex challenges. One major advantage of RPA in security is its ability to run 24/7 without interruption. Tasks that are time-consuming or repetitive for human employees can be efficiently managed by RPA, creating a more consistent layer of protection. Additionally, it can help businesses stay compliant with data regulations by automatically recording security actions and updates. Instead of relying on team members to complete these steps manually, RPA executes them precisely and on schedule. Automating Data Encryption Data encryption is one of the most important elements in a data security strategy, protecting sensitive information by converting it into an unreadable format. With encryption, data remains secure even if accessed by unauthorized users. However, manually encrypting data across all systems and applications is not only time-consuming but also prone to inconsistencies. Automating the encryption process enables businesses to apply real-time protection to data without the need for constant manual intervention. (adsbygoogle = window.adsbygoogle || []).push({}); Automated encryption solutions can detect sensitive data as it’s created or transferred and immediately encrypt it, adding a critical layer of security. This real-time approach is particularly valuable for businesses that handle large volumes of data daily. With automated encryption, businesses reduce the risk of accidental exposure, keeping data consistently protected, whether it’s at rest or in transit. Automation also allows companies to apply encryption uniformly across their systems so there are no weak points that hackers can exploit. Implementing Automated Security Audits Security audits play an essential role in identifying vulnerabilities, maintaining compliance, and ensuring data integrity. However, conducting regular audits can be a challenge for companies, as it requires significant time and resources. Automated audit tools streamline this process, allowing for continuous auditing that keeps an eye on security status in real time. Instead of waiting for scheduled audit periods, automated audits can provide up-to-date reports on security gaps and compliance status. Real-time auditing brings numerous benefits, especially for companies in highly regulated industries. Automated audits allow businesses to spot potential issues early, minimizing the risk of non-compliance and giving them a proactive approach to risk management. With continuous monitoring, teams can quickly act when issues arise, addressing vulnerabilities before they become major threats. Automated security audits give businesses the confidence that their security measures are consistently monitored and aligned with industry standards, all while reducing the workload on internal teams. Utilizing Machine Learning for Anomaly Detection Machine learning (ML) adds another layer of sophistication to automated security audits by identifying patterns and unusual activities that might indicate a security threat. Unlike traditional methods, ML algorithms can learn from data over time, recognizing what constitutes typical behaviour and quickly spotting anomalies that could signal unauthorized access or suspicious actions. This type of real-time detection helps teams stay aware of issues that may otherwise go unnoticed in large datasets. Incorporating ML into security audits enables businesses to gain a proactive approach to data protection. As soon as an anomaly is detected, ML-powered tools can alert the security team to investigate before any real damage is done. This level of insight is especially valuable in industries handling sensitive data, where even minor incidents could have serious consequences. Automated anomaly detection keeps teams informed, enabling swift action and strengthening the overall security framework. (adsbygoogle = window.adsbygoogle || []).push({}); Improving Data Access Control Statistics show that over 70% of organizations with access control experience fewer than five major incidents annually. Access control is a fundamental element of data security as it determines who can view or modify sensitive information within an organization. Automated access control systems make this process more secure by continuously monitoring and adjusting permissions based on predefined rules. For instance, when an employee changes roles or leaves the company, automated systems can immediately update or revoke access rights, reducing the risk of unauthorized access. Automating access control brings consistency and reduces human error, which can often lead to accidental exposure of sensitive information. By leveraging automated systems, companies create a more adaptable and secure environment where access is restricted to those who genuinely need it. This method also simplifies compliance with regulatory standards that require strict access controls. In this way, businesses can manage data access dynamically and respond quickly to personnel or organizational changes. Automated Reporting Automated reporting is a powerful tool for maintaining a clear view of an organization’s security health. With real-time data feeding directly into dashboards and reports, security teams gain immediate insights into the status of various security measures, compliance levels, and potential risks. Instead of spending hours manually compiling data for reports, automated systems handle this work, generating up-to-date summaries that decision-makers can access at any time. Automated reports not only save time but also improve the quality of information used in decision-making. These reports are frequently customizable, allowing teams to focus on specific metrics or risks that are most relevant to their organization. This flexibility makes it easier to make informed decisions, as leaders have a continuous, accurate view of security issues and trends. Automating data encryption and security audits has transformed the way businesses approach data protection. With tools like robotic process automation , machine learning, and automated reporting, companies can create a dynamic, secure environment that operates around the clock. These methods bring real-time data security and compliance monitoring within reach, helping organizations respond to risks proactively rather than reactively. (adsbygoogle = window.adsbygoogle || []).push({}); RELATED TOPICS Top 9 Compliance Automation Software in 2024 Safe Data Sharing Practices: How to Avoid Data Leaks How To Prevent Growing Issue of Encryption Based Malware How FHE Technology Is Making End-to-End Encryption a Reality Cybersecurity, Big Data & Automation Tools: What You Need To KnowMANCHESTER, England (AP) — Manchester City's players were booed by their own fans Tuesday after blowing a three-goal lead against Feyenoord in the Champions League to extend their winless run to six games. Jeers rang around the Etihad Stadium after the final whistle of a dramatic 3-3 draw. After five-straight losses in all competitions, City looked to be cruising to victory after going three up inside 50 minutes. But Feyenoord mounted an improbable comeback and leveled the game in the 89th minute to leave the home crowd stunned. While the worst losing streak of Guardiola’s managerial career was brought to an end, his wait for a first win since Oct. 26 goes on. Erling Haaland had scored twice, with Ilkay Gundogan also on target to put City in control. But goals from Anis Hadj Moussa in the 75th, Santiago Gimenez in the 82nd and David Hancko in the 89th turned the game on its head. City's players, including Bernardo Silva, Josko Gvardiol and Haaland looked visibly frustrated as they left the field to cheers of the delirious traveling Dutch fans in the away section of the stadium. City plays Premier League leader Liverpool on Sunday — defeat would leave it 11 points adrift of its title rival. ___ James Robson is at https://twitter.com/jamesalanrobson ___ AP soccer: https://apnews.com/hub/soccer James Robson, The Associated Press

Mind on Money: The future unfolds one day at a time

Prince William and Kate Middleton are currently first in line for the British throne; in 2022, after Queen Elizabeth II’s death, King Charles and his wife, Camilla Parker Bowles, were crowned. Although William and Kate don’t have the ability to change too much right now, they have done things a little bit differently than royals before them. William and Kate have continued to put their family and health ahead of the monarchy, and one expert says that when the two become king and queen, we might see big changes to royal Christmas traditions , too. Prince William and Kate Middleton could change some royal traditions when crowned William and Kate have experienced a year like no other; William even referred to it as “brutal.” In early 2024, Kate was diagnosed with cancer , and she stepped away from the spotlight for several months to undergo treatment. Before discussing her diagnosis, people began to spread rumors about everything from her marriage to her death, and it took its toll on the royal family. But once Kate explained her medical diagnosis, people gave her some much-needed space. During her road to recovery, William and Kate learned the value of always putting their family first. They have three kids, Prince George (11), Princess Charlotte (9), and Prince Louis (6), and when it comes to Christmas, their family traditions are important. One expert claims William and Kate could change some things about the holiday when they become king and queen. “I don’t think they worry particularly about how they’re perceived at Christmas, but I do think that Catherine and William want to do things in a more normal way,” royal expert Jennie Bond told OK! Magazine UK, according to Express . “They are lucky because they have their own home close to Sandringham, so they’ve always been able to wake up there, do stockings and presents and then go over to the big house for the more formal celebrations.” Bond continued, “I suspect that when they are king and queen a lot of traditions will change — and the exchange of presents on Christmas Eve may well be one of them.” Prince William and Kate Middleton are in no rush to become king and queen William and Kate are not worried about taking the throne right now. The couple seem to enjoy having the freedom to stress less about the royal family, and they have made it clear that their own little family is what’s truly important. In 2022, William and Kate even moved out of Kensington Palace and into Adelaide Cottage in order to offer their family a more private life. Right now, the Wales children are in the thick of their childhood, and William and Kate seemingly enjoy being able to closely watch them grow up.

Thirty years: Renaissance Quebec celebrates its social, economic and environmental missionsJones scores 22 and Fairleigh Dickinson downs Lehman 98-54